HitPredict

Interactor 1: F261 (P16118)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 (6PF-2-K/Fru-2,6-P2ase 1) (PFK/FBPase 1) (6PF-2-K/Fru-2,6-P2ase liver isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Gene: PFKFB1

Interactor 2: F264 (Q16877)
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (6PF-2-K/Fru-2,6-P2ase 4) (PFK/FBPase 4) (6PF-2-K/Fru-2,6-P2ase testis-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Gene: PFKFB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.858

The method score is based on:

Property Details
Experiments 32296183, 33961781, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains 6PF2K~6PF2K, 6PF2K~His_Phos_1, His_Phos_1~His_Phos_1
Common GO terms GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006000 - fructose metabolic process
and 1 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 471
Hs

1 469
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Last updated: 15 Jul 2024