HitPredict

Interactor 1: SPTCA (P13395)
Spectrin alpha chain
Gene: alpha-Spec

Interactor 2: SPTCB (Q00963)
Spectrin beta chain
Gene: beta-Spec

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 1.00 0.898

The method score is based on:

Property Details
Experiments 11076973, 7971971, 25381248, 38944040, unassigned4
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, experimental interaction detection
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains CH~EF-hand_7, EF-hand_7~Spectrin, CH~EFhand_Ca_insen, EFhand_Ca_insen~Spectrin, CH~Spectrin, Spectrin~Spectrin
Common GO terms GO:0005516 - calmodulin binding
GO:0005886 - plasma membrane
GO:0007026 - negative regulation of microtubule depolymerization
GO:0007274 - neuromuscular synaptic transmission
GO:0008017 - microtubule binding
and 14 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 2415
Dm

1 2291
+ Rn
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+ Mm
+ Dm
+ Dm
+ Dm
+ Rn
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+ Hs
+ Dm
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+ Dm
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+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025