HitPredict

Interactor 1: CCL5 (P13501)
C-C motif chemokine 5 (EoCP) (Eosinophil chemotactic cytokine) (SIS-delta) (Small-inducible cytokine A5) (T cell-specific protein P228) (TCP228) (T-cell-specific protein RANTES) [Cleaved into: RANTES(3-68); RANTES(4-68)]
Gene: CCL5

Interactor 2: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0008009 - chemokine activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 91 Hs			1 107
+	Hs
		626429 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00
+	Hs
		390338 CCL13_HUMAN (1-90): 5.72e-36: 118: 31.87		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		390315 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		390327 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78
+	Hs
		390401 CCL13_HUMAN (1-90): 5.72e-36: 118: 31.87		CXL10_HUMAN (17-102): 3.02e-22: 84.7: 27.27
+	Hs
		390372 CCL13_HUMAN (1-90): 5.72e-36: 118: 31.87		PLF4_HUMAN (40-103): 4.63e-21: 82: 43.75
+	Hs
		158953 CCL13_HUMAN (1-90): 5.72e-36: 118: 31.87		CXL11_HUMAN (21-103): 8.79e-21: 80.9: 28.24
+	Hs
		1059098 CCL13_HUMAN (1-90): 5.72e-36: 118: 31.87		CXCL9_HUMAN (33-99): 2.92e-20: 80.5: 47.06
+	Hs
		518755 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		IL8_HUMAN (25-107): 4.58e-25: 92: 40.00
+	Hs
		518775 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		IL8_HUMAN (25-107): 4.58e-25: 92: 40.00
+	Hs
		1009598 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		CXCL6_HUMAN (30-104): 1.16e-24: 91.6: 40.00
+	Hs
		562888 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		CXCL6_HUMAN (30-104): 1.16e-24: 91.6: 40.00
+	Hs
		231420 CC4L_HUMAN (1-91): 2.17e-31: 107: 44.57		CXL13_HUMAN (38-107): 6.78e-22: 84.3: 25.35
+	Hs
		390380 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		CXL10_HUMAN (17-102): 3.02e-22: 84.7: 27.27
+	Hs
		390392 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		CXL10_HUMAN (17-102): 3.02e-22: 84.7: 27.27
+	Hs
		390357 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		PLF4_HUMAN (40-103): 4.63e-21: 82: 43.75
+	Hs
		158930 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		CXL11_HUMAN (21-103): 8.79e-21: 80.9: 28.24
+	Hs
		158945 CCL8_HUMAN (1-90): 4.8e-31: 106: 36.96		CXL11_HUMAN (21-103): 8.79e-21: 80.9: 28.24
+	Hs
		562893 CCL5_HUMAN (1-91): 4.45e-31: 106: 100.00		CXCL9_HUMAN (33-99): 2.92e-20: 80.5: 47.06
+	Hs
		532026 CC4L_HUMAN (1-91): 2.17e-31: 107: 44.57		PF4V_HUMAN (40-103): 5.48e-19: 76.6: 40.63