HitPredict

Interactor 1: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Interactor 2: CCL8 (P80075)
C-C motif chemokine 8 (HC14) (Monocyte chemoattractant protein 2) (Monocyte chemotactic protein 2) (MCP-2) (Small-inducible cytokine A8) [Cleaved into: MCP-2(6-76)]
Gene: CCL8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	28381538
Identification Methods	pull down, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0008009 - chemokine activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 99
+	Hs
		390338 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CCL13_HUMAN (1-98): 3.22e-37: 122: 62.25
+	Hs
		626428 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CCL11_HUMAN (1-99): 2.28e-31: 107: 68.69
+	Hs
		626442 CXCL3_HUMAN (1-107): 9.67e-32: 109: 87.85		CCL11_HUMAN (1-99): 2.28e-31: 107: 68.69
+	Hs
		390327 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CCL8_HUMAN (1-99): 5.19e-35: 116: 100.00
+	Hs
		480491 GROA_HUMAN (1-107): 2.32e-31: 108: 89.72		CCL11_HUMAN (1-99): 2.28e-31: 107: 68.69
+	Hs
		518775 IL8_HUMAN (25-107): 4.58e-25: 92: 40.00		CCL8_HUMAN (1-99): 5.19e-35: 116: 100.00
+	Hs
		562867 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		518754 IL8_HUMAN (25-107): 4.58e-25: 92: 40.00		CCL2_HUMAN (1-98): 9.74e-33: 111: 69.39
+	Hs
		626425 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		XCL1_HUMAN (7-97): 1.01e-23: 88.9: 29.67
+	Hs
		843120 CXCL5_HUMAN (29-104): 3.06e-26: 95.5: 46.05		CCL11_HUMAN (1-99): 2.28e-31: 107: 68.69
+	Hs
		626437 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		XCL2_HUMAN (7-97): 1.92e-23: 88.1: 29.67
+	Hs
		141745 CXCL2_HUMAN (1-107): 5.53e-34: 114: 100.00		CCL21_HUMAN (24-99): 2.48e-21: 83.1: 32.91
+	Hs
		626448 CXCL3_HUMAN (1-107): 9.67e-32: 109: 87.85		XCL2_HUMAN (7-97): 1.92e-23: 88.1: 29.67
+	Hs
		390315 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		390347 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CCL26_HUMAN (23-95): 4.81e-23: 86.6: 35.62
+	Hs
		518755 IL8_HUMAN (25-107): 4.58e-25: 92: 40.00		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		562888 CXCL6_HUMAN (30-104): 1.16e-24: 91.6: 40.00		CCL5_HUMAN (1-92): 1.3e-25: 92.7: 35.87
+	Hs
		843132 CXCL5_HUMAN (29-104): 3.06e-26: 95.5: 46.05		XCL2_HUMAN (7-97): 1.92e-23: 88.1: 29.67
+	Hs
		141738 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CCL21_HUMAN (24-99): 2.48e-21: 83.1: 32.91
+	Hs
		843121 CXCL5_HUMAN (29-104): 3.06e-26: 95.5: 46.05		CCL20_HUMAN (5-97): 3.29e-20: 79.2: 26.60