HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: DESM (P17661)
Desmin
Gene: DES

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005634 - nucleus GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 470
+	Hs
		474434 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		VIME_HUMAN (28-469): 1.75e-150: 438: 62.19
+	Hs
		474521 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		VIME_HUMAN (28-469): 1.75e-150: 438: 62.19
+	Hs
		437069 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C8_HUMAN (81-464): 3.23e-139: 410: 35.01
+	Hs
		437110 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C8_HUMAN (81-464): 3.23e-139: 410: 35.01
+	Hs
		551541 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		PERI_HUMAN (12-470): 2.14e-134: 397: 59.14
+	Hs
		551534 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		DESM_HUMAN (1-470): 9.86e-110: 334: 100.00
+	Hs
		606081 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		DESM_HUMAN (1-470): 9.86e-110: 334: 100.00
+	Hs
		551596 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT84_HUMAN (2-416): 8.61e-102: 318: 31.29
+	Hs
		341729 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C75_HUMAN (9-427): 3.01e-88: 281: 33.33
+	Hs
		341741 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C75_HUMAN (9-427): 3.01e-88: 281: 33.33
+	Hs
		551555 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K1H2_HUMAN (29-425): 1.03e-78: 253: 26.50
+	Hs
		551532 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C5_HUMAN (74-419): 2.75e-74: 246: 35.04
+	Hs
		300547 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT36_HUMAN (7-470): 6.97e-75: 244: 25.84
+	Hs
		551578 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT35_HUMAN (19-422): 6.09e-75: 244: 28.50
+	Hs
		385226 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		K2C6A_HUMAN (11-435): 4.2e-73: 242: 29.30
+	Hs
		566337 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C5_HUMAN (74-419): 2.75e-74: 246: 35.04
+	Hs
		300552 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		KRT36_HUMAN (7-470): 6.97e-75: 244: 25.84
+	Hs
		385242 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		K2C6A_HUMAN (11-435): 4.2e-73: 242: 29.30
+	Hs
		300622 K2C3_HUMAN (140-484): 3.96e-178: 519: 78.10		KRT37_HUMAN (5-432): 5.94e-69: 228: 28.31
+	Hs
		300634 K22E_HUMAN (140-484): 3.02e-174: 509: 71.88		KRT37_HUMAN (5-432): 5.94e-69: 228: 28.31