HitPredict

Interactor 1: KRT36 (O76013)
Keratin, type I cuticular Ha6 (Hair keratin, type I Ha6) (Keratin-36) (K36)
Gene: KRT36

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, validated two hybrid, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0030280 - structural constituent of skin epidermis GO:0045095 - keratin filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 467 Hs			1 639
+	Hs
		437152 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33
+	Hs
		385035 K1C14_HUMAN (4-466): 1.85e-147: 430: 49.90		K2C8_HUMAN (150-535): 1.3e-143: 427: 59.33
+	Hs
		475754 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C7_HUMAN (86-542): 4.84e-131: 395: 52.62
+	Hs
		407432 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C1_HUMAN (143-509): 1.14e-110: 348: 71.94
+	Hs
		385032 K1C14_HUMAN (4-466): 1.85e-147: 430: 49.90		K2C1_HUMAN (143-509): 1.14e-110: 348: 71.94
+	Hs
		1047491 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		KRT84_HUMAN (5-576): 1.24e-102: 326: 44.43
+	Hs
		341758 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C75_HUMAN (1-582): 1.21e-89: 290: 53.07
+	Hs
		341718 K1C14_HUMAN (4-466): 1.85e-147: 430: 49.90		K2C75_HUMAN (1-582): 1.21e-89: 290: 53.07
+	Hs
		227197 K1C14_HUMAN (4-466): 1.85e-147: 430: 49.90		KRT86_HUMAN (72-493): 1.23e-87: 283: 48.23
+	Hs
		407275 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C6B_HUMAN (5-510): 2.01e-82: 272: 61.22
+	Hs
		876459 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C6C_HUMAN (5-510): 7.1e-82: 270: 61.61
+	Hs
		385031 K1C14_HUMAN (4-466): 1.85e-147: 430: 49.90		K2C6B_HUMAN (5-510): 2.01e-82: 272: 61.22
+	Hs
		566362 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C5_HUMAN (1-494): 1.41e-80: 267: 61.08
+	Hs
		1047431 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C79_HUMAN (33-568): 3.25e-79: 262: 55.08
+	Hs
		385261 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C6A_HUMAN (5-510): 2.13e-78: 261: 61.22
+	Hs
		385028 K1C14_HUMAN (4-466): 1.85e-147: 430: 49.90		K2C6A_HUMAN (5-510): 2.13e-78: 261: 61.22
+	Hs
		1047416 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C72_HUMAN (1-494): 5.11e-76: 253: 55.26
+	Hs
		1030977 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K22O_HUMAN (1-497): 1.02e-73: 251: 61.34
+	Hs
		777446 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K22E_HUMAN (1-517): 1.58e-67: 234: 100.00
+	Hs
		1047441 K1C17_HUMAN (85-465): 3.75e-149: 433: 56.69		K2C1B_HUMAN (58-509): 1.83e-65: 227: 61.50