HitPredict

Interactor 1: PTN2 (P17706)
Tyrosine-protein phosphatase non-receptor type 2 (EC 3.1.3.48) (T-cell protein-tyrosine phosphatase) (TCPTP)
Gene: PTPN2

Interactor 2: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.776

Property	Details
Experiments	19171783, 12171910
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~Y_phosphatase
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 415 Hs			1 750
+	Hs
		570489 PTN2_HUMAN (1-415): 2.43e-175: 497: 100.00		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Mm
		665977 PTN6_MOUSE (2-351): 1.79e-128: 384: 28.57		STAT1_MOUSE (1-750): 0: 969: 92.27
+	Hs
		573602 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Mm
		786649 PTN2_MOUSE (1-411): 6.2e-168: 478: 89.29		STA5A_MOUSE (1-748): 0: 793: 27.79
+	Mm
		786664 PTN2_MOUSE (1-411): 6.2e-168: 478: 89.29		STA5B_MOUSE (1-748): 0: 782: 28.13
+	Hs
		665813 PTN6_HUMAN (2-351): 4.45e-132: 393: 27.78		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Mm
		665978 PTN6_MOUSE (2-351): 1.79e-128: 384: 28.57		STAT3_MOUSE (1-740): 0: 865: 52.61
+	Hs
		573623 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		STA5B_HUMAN (1-749): 0: 787: 28.82
+	Hs
		573605 PTN1_HUMAN (4-413): 1e-158: 455: 51.93		STA5A_HUMAN (1-748): 0: 780: 28.14
+	Hs
		665833 PTN6_HUMAN (2-351): 4.45e-132: 393: 27.78		STA5B_HUMAN (1-749): 0: 787: 28.82
+	Hs
		786325 PTN11_HUMAN (32-272): 1.6e-47: 172: 39.00		STAT1_HUMAN (1-750): 0: 988: 100.00
+	Hs
		570493 PTN2_HUMAN (1-415): 2.43e-175: 497: 100.00		STAT6_HUMAN (1-740): 0: 638: 26.43
+	Hs
		146922 PTPRT_HUMAN (4-276): 8.71e-63: 220: 23.88		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Hs
		776659 PTN11_HUMAN (32-272): 1.6e-47: 172: 39.00		STAT3_HUMAN (1-740): 0: 864: 52.61
+	Mm
		719288 PTN11_MOUSE (32-272): 1.17e-47: 173: 39.00		STA5A_MOUSE (1-748): 0: 793: 27.79
+	Hs
		849884 PTN11_HUMAN (32-272): 1.6e-47: 172: 39.00		STA5B_HUMAN (1-749): 0: 787: 28.82
+	Hs
		786601 PTN11_HUMAN (32-272): 1.6e-47: 172: 39.00		STA5A_HUMAN (1-748): 0: 780: 28.14