HitPredict

Interactor 1: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Interactor 2: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35563538
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 439 Hs			1 768
+	Hs
		906824 PRS4_HUMAN (32-433): 5.45e-136: 399: 43.60		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		907019 PRS8_HUMAN (65-437): 1.93e-126: 373: 44.39		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		798654 PRS6B_HUMAN (8-438): 1.04e-118: 354: 37.59		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		874907 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		1042056 AFG2A_HUMAN (182-435): 3.65e-68: 234: 35.32		CUL3_HUMAN (1-768): 0: 951: 100.00
+	Hs
		874908 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		CUL4A_HUMAN (10-768): 0: 791: 38.32
+	Hs
		874909 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		CUL4B_HUMAN (5-768): 0: 779: 36.77
+	Hs
		874905 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		CUL1_HUMAN (18-768): 0: 707: 30.57
+	Hs
		874906 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		CUL2_HUMAN (30-768): 0: 672: 26.17
+	Dm
		1097193 TERA_DROME (17-419): 5.11e-77: 257: 25.81		CUL1_DROME (29-768): 0: 669: 27.49
+	Hs
		875192 TERA_HUMAN (162-434): 9.21e-77: 256: 35.17		CUL5_HUMAN (25-768): 0: 597: 23.77
+	Sc
		636771 CDC48_YEAST (144-419): 9.98e-80: 265: 37.32		CDC53_YEAST (30-768): 0: 573: 22.08