Protein: DUS14
Dual specificity protein phosphatase 14 (EC 3.1.3.16) (EC 3.1.3.48) (MKP-1-like protein tyrosine phosphatase) (MKP-L) (Mitogen-activated protein kinase phosphatase 6) (MAP kinase phosphatase 6) (MKP-6)

Gene: DUS14, DUSP14
Organism: Homo sapiens
Interactions: 184
UniProt ID: O95147

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0017017 - MAP kinase tyrosine/serine/threonine phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

326677

MK09
Mitogen-activated protein kinase 9

3

20

High-throughput

0.770

High

326747

IL31R
Interleukin-31 receptor subunit alpha

2

2

High-throughput

0.726

High

326657

EPHA1
Ephrin type-A receptor 1

1

18

High-throughput

0.625

High

326661

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.625

High

326684

DUS3
Dual specificity protein phosphatase 3

1

20

High-throughput

0.618

High

326762

OTUL
Ubiquitin thioesterase otulin

3

1

High-throughput

0.609

High

326778

O51E2
Olfactory receptor 51E2

3

1

High-throughput

0.609

High

326731

GPBP1
Vasculin

2

0

High-throughput

0.602

High

326781

HEAT1
HEAT repeat-containing protein 1

2

0

High-throughput

0.602

High

326760

FUBP2
Far upstream element-binding protein 2

2

9

High-throughput

0.601

High

190034

FOXP2
Forkhead box protein P2

2

1

High-throughput

0.574

High

326644

MAS
Proto-oncogene Mas

2

2

High-throughput

0.574

High

326703

ACOX1
Peroxisomal acyl-coenzyme A oxidase 1

2

1

High-throughput

0.574

High

326718

LPCT4
Lysophospholipid acyltransferase LPCAT4

2

2

High-throughput

0.574

High

326732

RFIP4
Rab11 family-interacting protein 4

2

7

High-throughput

0.574

High

326749

GRP4
RAS guanyl-releasing protein 4

2

1

High-throughput

0.574

High

326755

FAN
Protein FAN

2

1

High-throughput

0.574

High

326767

RM38
Large ribosomal subunit protein mL38

2

1

High-throughput

0.574

High

326777

RHBT2
Rho-related BTB domain-containing protein 2

2

6

High-throughput

0.574

High

326794

FBXL4
F-box/LRR-repeat protein 4

2

3

High-throughput

0.574

High

326796

ACAD8
Isobutyryl-CoA dehydrogenase, mitochondrial

2

1

High-throughput

0.574

High

326804

KIF3A
Kinesin-like protein KIF3A

2

4

High-throughput

0.574

High

326698

TRAF2
TNF receptor-associated factor 2

2

8

Small-scale

0.570

High

326664

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

2

1

High-throughput

0.558

High

326699

COASY
Bifunctional coenzyme A synthase

2

1

High-throughput

0.558

High

326706

RB11B
Ras-related protein Rab-11B

2

3

High-throughput

0.558

High

326730

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

1

High-throughput

0.558

High

326764

P5CR2
Pyrroline-5-carboxylate reductase 2

2

1

High-throughput

0.558

High

326647

INSR
Insulin receptor

1

20

High-throughput

0.553

High

284031

SRS10
Serine/arginine-rich splicing factor 10

1

7

High-throughput

0.536

High

326803

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.536

High

258403

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.513

High

326745

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.513

High

326782

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.513

High

326645

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.494

High

326648

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.494

High

326658

FGFR2
Fibroblast growth factor receptor 2

1

20

High-throughput

0.494

High

326659

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.494

High

326693

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.494

High

326694

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.494

High

326700

PTK7
Inactive tyrosine-protein kinase 7

1

12

High-throughput

0.494

High

326705

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.494

High

326725

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.494

High

326734

LMTK2
Serine/threonine-protein kinase LMTK2

1

20

High-throughput

0.494

High

126035

AP3B1
AP-3 complex subunit beta-1

1

1

High-throughput

0.489

High

133831

FOXN3
Forkhead box protein N3

1

2

High-throughput

0.489

High

326638

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

High-throughput

0.489

High

326666

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.489

High

326678

CAZA2
F-actin-capping protein subunit alpha-2

1

4

High-throughput

0.489

High

326679

RGR
RPE-retinal G protein-coupled receptor

1

1

High-throughput

0.489

High

326683

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

3

High-throughput

0.489

High

326690

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

1

High-throughput

0.489

High

326716

TMTC4
Protein O-mannosyl-transferase TMTC4

1

3

High-throughput

0.489

High

326721

WDR59
GATOR2 complex protein WDR59

1

1

High-throughput

0.489

High

326726

DYM
Dymeclin

1

1

High-throughput

0.489

High

326728

DSG4
Desmoglein-4

1

3

High-throughput

0.489

High

326729

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

1

High-throughput

0.489

High

326737

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

2

High-throughput

0.489

High

326758

US6NL
USP6 N-terminal-like protein

1

1

High-throughput

0.489

High

326765

RB39B
Ras-related protein Rab-39B

1

6

High-throughput

0.489

High

326774

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

3

High-throughput

0.489

High

326779

SRMS
Tyrosine-protein kinase Srms

1

8

High-throughput

0.489

High

326785

SPTC3
Serine palmitoyltransferase 3

1

1

High-throughput

0.489

High

326792

NOCT
Nocturnin

1

1

High-throughput

0.489

High

326793

FBX3
F-box only protein 3

1

1

High-throughput

0.489

High

326802

RT18C
Small ribosomal subunit protein bS18m

1

1

High-throughput

0.489

High

326805

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.480

High

250383

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

4

High-throughput

0.479

High

326653

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

326654

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

7

High-throughput

0.479

High

326660

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

High-throughput

0.479

High

326670

RBMX
RNA-binding motif protein, X chromosome

1

7

High-throughput

0.479

High

326674

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

10

High-throughput

0.479

High

326676

MATR3
Matrin-3

1

5

High-throughput

0.479

High

326685

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

6

High-throughput

0.479

High

326689

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

9

High-throughput

0.479

High

326692

RT35
Small ribosomal subunit protein mS35

1

2

High-throughput

0.479

High

326708

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

High-throughput

0.479

High

326709

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

5

High-throughput

0.479

High

326712

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.479

High

326717

TENS2
Tensin-2

1

1

High-throughput

0.479

High

326736

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

High-throughput

0.479

High

326754

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

1

7

High-throughput

0.479

High

326771

FUBP3
Far upstream element-binding protein 3

1

9

High-throughput

0.479

High

326772

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

326788

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

High-throughput

0.479

High

326807

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

10

High-throughput

0.479

High

288879

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.458

High

326786

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.458

High

326787

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

326801

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.458

High

326656

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

2

High-throughput

0.445

High

281845

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.437

High

326639

DLGP3
Disks large-associated protein 3

1

1

High-throughput

0.437

High

326641

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.437

High

326642

A2MG
Alpha-2-macroglobulin

1

2

High-throughput

0.437

High

326668

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.437

High

326680

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.437

High

326710

Q4LE69
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.437

High

326746

FAD1
FAD synthase

1

1

High-throughput

0.437

High

326748

LNX1
E3 ubiquitin-protein ligase LNX

1

6

Small-scale

0.437

High

326756

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

326798

UBP18
Ubl carboxyl-terminal hydrolase 18

1

10

Small-scale

0.437

High

326649

HS90B
Heat shock protein HSP 90-beta

1

0

High-throughput

0.426

High

326651

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.426

High

326672

PI4KA
Phosphatidylinositol 4-kinase alpha

1

3

High-throughput

0.407

High

326750

DLG5
Disks large homolog 5

1

4

High-throughput

0.407

High

326761

PEX13
Peroxisomal membrane protein PEX13

1

3

High-throughput

0.407

High

326780

E41L1
Band 4.1-like protein 1

1

1

High-throughput

0.407

High

292282

B3GL1
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1

3

0

High-throughput

0.347

High

326711

SGO2
Shugoshin 2

3

0

High-throughput

0.347

High

326733

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.347

High

326757

TFG
Protein TFG

3

0

High-throughput

0.347

High

326759

PMM1
Phosphomannomutase 1

3

0

High-throughput

0.347

High

326768

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

326770

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

3

0

High-throughput

0.347

High

326675

GDF5
Growth/differentiation factor 5

2

0

High-throughput

0.328

High

326697

CF210
Cilia- and flagella- associated protein 210

2

0

High-throughput

0.328

High

326707

SYT16
Synaptotagmin-16

2

0

High-throughput

0.328

High

326719

IFIX
Pyrin and HIN domain-containing protein 1

2

0

High-throughput

0.328

High

326743

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

2

0

High-throughput

0.328

High

326753

CPLX3
Complexin-3

2

0

High-throughput

0.328

High

326763

F136A
Protein FAM136A

2

0

High-throughput

0.328

High

326775

SETB2
Histone-lysine N-methyltransferase SETDB2

2

0

High-throughput

0.328

High

326799

OAZ3
Ornithine decarboxylase antizyme 3

2

0

High-throughput

0.328

High

162415

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.301

High

326652

CD28
T-cell-specific surface glycoprotein CD28

1

0

Small-scale

0.299

High

326740

CBY2
Protein chibby homolog 2

1

0

High-throughput

0.299

High

326784

INO1
Inositol-3-phosphate synthase 1

1

0

High-throughput

0.282

High

253801

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

296600

TNF13
Tumor necrosis factor ligand superfamily member 13

1

0

High-throughput

0.279

Low

301788

ANXA9
Annexin A9

1

0

High-throughput

0.279

Low

326640

LGI1
Leucine-rich glioma-inactivated protein 1

1

0

High-throughput

0.279

Low

326643

FOS
Protein c-Fos

1

0

High-throughput

0.279

Low

326646

7B2
Neuroendocrine protein 7B2

1

0

High-throughput

0.279

Low

326650

TRFM
Melanotransferrin

1

0

High-throughput

0.279

Low

326655

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.279

Low

326662

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.279

Low

326665

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

326667

PROF2
Profilin-2

1

0

High-throughput

0.279

Low

326669

DRD3
D(3) dopamine receptor

1

0

High-throughput

0.279

Low

326671

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.279

Low

326681

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

326682

FNTB
Protein farnesyltransferase subunit beta

1

0

High-throughput

0.279

Low

326686

GSC
Homeobox protein goosecoid

1

0

High-throughput

0.279

Low

326687

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

326688

T2R38
Taste receptor type 2 member 38

1

0

High-throughput

0.279

Low

326696

ZN543
Zinc finger protein 543

1

0

High-throughput

0.279

Low

326701

ITAD
Integrin alpha-D

1

0

High-throughput

0.279

Low

326702

SPRL1
SPARC-like protein 1

1

0

High-throughput

0.279

Low

326704

PMVK
Phosphomevalonate kinase

1

0

High-throughput

0.279

Low

326713

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

326714

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.279

Low

326720

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

326723

NPSR1
Neuropeptide S receptor

1

0

High-throughput

0.279

Low

326724

HEPN1
Putative cancer susceptibility gene HEPN1 protein

1

0

High-throughput

0.279

Low

326727

LYG2
Lysozyme g-like protein 2

1

0

High-throughput

0.279

Low

326735

ORML3
ORM1-like protein 3

1

0

High-throughput

0.279

Low

326738

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

326739

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.279

Low

326742

TM35B
Transmembrane protein 35B

1

0

High-throughput

0.279

Low

326744

BHE23
Class E basic helix-loop-helix protein 23

1

0

High-throughput

0.279

Low

326751

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

326752

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

326766

SLAF6
SLAM family member 6

1

0

High-throughput

0.279

Low

326769

DTBP1
Dysbindin

1

0

High-throughput

0.279

Low

326776

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

0

High-throughput

0.279

Low

326783

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.279

Low

326789

NPAP1
Nuclear pore-associated protein 1

1

0

High-throughput

0.279

Low

326790

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

326795

NUDT5
ADP-sugar pyrophosphatase

1

0

High-throughput

0.279

Low

326797

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.279

Low

326800

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.279

Low

326691

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.249

Low

326695

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

0

High-throughput

0.249

Low

326741

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

326806

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.249

Low

261026

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

326663

ACHA3
Neuronal acetylcholine receptor subunit alpha-3

1

0

High-throughput

0.232

Low

326673

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.232

Low

326715

TMM31
Transmembrane protein 31

1

0

High-throughput

0.232

Low

326722

OLFM4
Olfactomedin-4

1

0

High-throughput

0.232

Low

326773

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.232

Low

326791

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025