Protein: DUS21
Dual specificity protein phosphatase 21 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21)

Gene: DUS21, DUSP21
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q9H596

Gene Ontology (top 5):
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1434546

DUS21
Dual specificity protein phosphatase 21

2

18

High-throughput

0.757

High

1097115

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

2

10

High-throughput

0.700

High

1434547

GORS2
Golgi reassembly-stacking protein 2

4

2

High-throughput

0.637

High

710661

EPHA3
Ephrin type-A receptor 3

1

20

High-throughput

0.625

High

443519

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.618

High

1194626

DUS28
Dual specificity phosphatase 28

1

17

High-throughput

0.618

High

1429488

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.618

High

1314994

TEX11
Testis-expressed protein 11

3

1

High-throughput

0.616

High

124650

EYA2
Protein phosphatase EYA2

2

1

High-throughput

0.606

High

288514

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

3

High-throughput

0.606

High

907192

SUOX
Sulfite oxidase, mitochondrial

2

2

High-throughput

0.606

High

941557

CTBP2
C-terminal-binding protein 2

2

1

High-throughput

0.606

High

1093955

TRAF1
TNF receptor-associated factor 1

2

4

High-throughput

0.606

High

1145944

PO4F3
POU domain, class 4, transcription factor 3

2

3

High-throughput

0.606

High

1434553

UBQL2
Ubiquilin-2

2

4

High-throughput

0.606

High

582622

PPAP
Prostatic acid phosphatase

2

0

High-throughput

0.595

High

217200

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

1272432

GET4
Golgi to ER traffic protein 4 homolog

2

0

High-throughput

0.580

High

1301009

RFX6
DNA-binding protein RFX6

2

0

High-throughput

0.580

High

1434551

CPNE7
Copine-7

2

0

High-throughput

0.580

High

1131394

GANAB
Neutral alpha-glucosidase AB

2

4

High-throughput

0.558

High

931897

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.555

High

1034193

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

20

High-throughput

0.541

High

1145779

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.541

High

123834

MYO1C
Unconventional myosin-Ic

1

12

High-throughput

0.536

High

227971

MYO1B
Unconventional myosin-Ib

1

13

High-throughput

0.536

High

135998

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

3

High-throughput

0.515

High

1395461

MY15B
Unconventional myosin-XVB

1

12

High-throughput

0.515

High

1256990

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

423167

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

465649

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.494

High

641674

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.494

High

1034344

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.494

High

1101779

PTK7
Inactive tyrosine-protein kinase 7

1

12

High-throughput

0.494

High

995478

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.489

High

1421378

ARP3C
Actin-related protein 3C

1

17

High-throughput

0.489

High

833433

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.486

High

190027

TOX3
TOX high mobility group box family member 3

1

2

High-throughput

0.481

High

1204695

ZMAT1
Zinc finger matrin-type protein 1

1

2

High-throughput

0.481

High

1434554

KLH20
Kelch-like protein 20

1

2

High-throughput

0.481

High

124496

HAX1
HCLS1-associated protein X-1

1

4

High-throughput

0.479

High

257574

TI17B
Mitochondrial import inner membrane translocase subunit Tim17-B

1

5

High-throughput

0.479

High

276523

PDCD6
Programmed cell death protein 6

1

5

High-throughput

0.479

High

354402

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

1

High-throughput

0.479

High

459918

APT
Adenine phosphoribosyltransferase

1

2

High-throughput

0.479

High

560098

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

3

High-throughput

0.479

High

635385

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

2

High-throughput

0.479

High

651875

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.479

High

761032

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

841948

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

11

High-throughput

0.479

High

899234

TCPQ
T-complex protein 1 subunit theta

1

6

High-throughput

0.479

High

910335

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

1

High-throughput

0.479

High

960562

PSME3
Proteasome activator complex subunit 3

1

4

High-throughput

0.479

High

1015124

ARF5
ADP-ribosylation factor 5

1

9

High-throughput

0.479

High

1121881

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

7

High-throughput

0.479

High

1407570

TCPH
T-complex protein 1 subunit eta

1

3

High-throughput

0.479

High

1411411

CAB45
45 kDa calcium-binding protein

1

7

High-throughput

0.479

High

1414089

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

1415383

DUS23
Dual specificity protein phosphatase 23

1

17

High-throughput

0.479

High

1434549

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

2

High-throughput

0.479

High

1434552

MTFP1
Mitochondrial fission process protein 1

1

1

High-throughput

0.479

High

1434555

KAD6
Adenylate kinase isoenzyme 6

1

2

High-throughput

0.479

High

1434556

MTCH2
Mitochondrial carrier homolog 2

1

6

High-throughput

0.479

High

1412201

Q9BS75
Kelch-like protein 20

1

3

High-throughput

0.470

High

715326

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

1

0

High-throughput

0.458

High

884793

SYSC
Serine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

1055970

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.458

High

1204949

MTX3
Metaxin-3

1

0

High-throughput

0.458

High

1210707

KMCP1
Kidney mitochondrial carrier protein 1

1

0

High-throughput

0.458

High

1294679

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.458

High

75724

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

2

High-throughput

0.437

High

130242

PGRC1
Membrane-associated progesterone receptor component 1

1

3

High-throughput

0.437

High

257673

PRAF2
PRA1 family protein 2

1

2

High-throughput

0.437

High

790950

TAGL2
Transgelin-2

1

6

High-throughput

0.437

High

1145685

RCN1
Reticulocalbin-1

1

5

High-throughput

0.437

High

1213609

QNG1
Queuosine 5'-phosphate N-glycosylase/hydrolase

1

1

High-throughput

0.437

High

1228778

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

1

2

High-throughput

0.437

High

1363700

TCPW
T-complex protein 1 subunit zeta-2

1

4

High-throughput

0.437

High

1391042

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.437

High

1419883

RAB34
Ras-related protein Rab-34

1

5

High-throughput

0.437

High

69551

A2ML1
Alpha-2-macroglobulin-like protein 1

1

2

High-throughput

0.407

High

1127683

KT33B
Keratin, type I cuticular Ha3-II

2

0

High-throughput

0.316

High

1239786

FAP20
Fanconi anemia core complex-associated protein 20

2

0

High-throughput

0.316

High

1307067

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.316

High

1434548

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.316

High

1434557

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.316

High

1434550

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025