HitPredict

Interactor 1: VINC (P18206)
Vinculin (Metavinculin) (MV)
Gene: VCL

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	30120307, 10330411, 9054445, 8922390, 34079125
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0005925 - focal adhesion GO:0007155 - cell adhesion and 1 others more... GO:0008013 - beta-catenin binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1134 Hs			1 591
+	Gg
		517021 VINC_CHICK (1-1134): 0: 880: 93.30		PAXI_CHICK (1-591): 3.03e-128: 389: 83.11
+	Hs
		238947 VINC_HUMAN (1-1134): 0: 893: 100.00		LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37
+	Mm
		1145497 VINC_MOUSE (1-1134): 0: 811: 90.65		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		200161 VINC_HUMAN (1-1134): 0: 893: 100.00		TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91
+	Hs
		575811 VINC_HUMAN (1-1134): 0: 893: 100.00		LPP_HUMAN (472-590): 5.36e-23: 105: 26.23
+	Hs
		575867 VINC_HUMAN (1-1134): 0: 893: 100.00		LIMD1_HUMAN (467-588): 1.05e-22: 104: 22.48
+	Mm
		1145496 VINC_MOUSE (1-1134): 0: 811: 90.65		PDLI5_MOUSE (530-590): 7.68e-11: 66.9: 34.43
+	Ce
		587390 VINC_CAEEL (1-1132): 0: 674: 26.08		PXL1_CAEEL (143-532): 1.7e-57: 200: 19.75
+	Dm
		220698 VINC_DROME (1-933): 5.44e-126: 411: 28.23		Q2PDT4_DROME (66-590): 3.69e-91: 294: 47.66
+	Dm
		220702 VINC_DROME (1-933): 5.44e-126: 411: 28.23		Q8INW7_DROME (66-590): 9.36e-90: 289: 47.66
+	Dm
		220705 VINC_DROME (1-933): 5.44e-126: 411: 28.23		Q9VIX2_DROME (4-532): 8.28e-46: 172: 19.07
+	Hs
		823521 TLN1_HUMAN (33-1112): 2.04e-52: 204: 12.22		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		716782 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		716742 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		LPP_HUMAN (472-590): 5.36e-23: 105: 26.23
+	Hs
		716799 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		LIMD1_HUMAN (467-588): 1.05e-22: 104: 22.48
+	Hs
		150531 CTNA1_HUMAN (5-899): 1.05e-65: 241: 15.48		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32
+	Mm
		640172 TLN1_MOUSE (54-1125): 3.27e-16: 86.7: 11.40		FHL1_MOUSE (351-471): 2.28e-27: 113: 26.19