Interactor 1: IL1RA (P18510)
Interleukin-1 receptor antagonist protein (IL-1RN) (IL-1ra) (IRAP) (ICIL-1RA) (IL1 inhibitor) (Anakinra)
Gene: IL1RN

Interactor 2: IL1R2 (P27930)
Interleukin-1 receptor type 2 (IL-1R-2) (IL-1RT-2) (IL-1RT2) (CD121 antigen-like family member B) (CDw121b) (IL-1 type II receptor) (Interleukin-1 receptor beta) (IL-1R-beta) (Interleukin-1 receptor type II) (CD antigen CD121b) [Cleaved into: Interleukin-1 receptor type 2, membrane form (mIL-1R2) (mIL-1RII); Interleukin-1 receptor type 2, soluble form (sIL-1R2) (sIL-1RII)]
Gene: IL1R2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 1834644, 1833184
Identification Methods affinity chromatography technology, competition binding
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IL1~ig
Common GO terms GO:0005886 - plasma membrane
GO:0006955 - immune response
GO:2000660 - negative regulation of interleukin-1-mediated signaling pathway
Homologous interactions 9

Homologous interactions

Color coding for hit scores

1 177
Hs

1 398
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024