Protein: ETS2
Protein C-ets-2

Gene: ETS2
Organism: Homo sapiens
Interactions: 57
UniProt ID: P15036

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

540797

ERG
Transcriptional regulator ERG

2

18

Small-scale

0.783

High

578307

COP1
E3 ubiquitin-protein ligase COP1

3

19

Small-scale

0.684

High

413120

P53
Cellular tumor antigen p53

3

5

Small-scale

0.675

High

578297

CDK10
Cyclin-dependent kinase 10

3

1

Small-scale

0.672

High

578311

CBP
CREB-binding protein

3

20

Small-scale

0.667

High

578298

ZMY11
Zinc finger MYND domain-containing protein 11

2

20

Small-scale

0.651

High

577394

ETS1
Protein C-ets-1

1

19

Small-scale

0.647

High

578286

SPI1
Transcription factor PU.1

1

17

Small-scale

0.647

High

578293

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

12

Small-scale

0.646

High

578296

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.635

High

578301

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.582

High

578303

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

1

0

High-throughput

0.578

High

578295

PO5F1
POU domain, class 5, transcription factor 1

1

10

Small-scale

0.561

High

578312

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

9

Small-scale

0.561

High

450166

GDN
Glia-derived nexin

1

5

High-throughput

0.541

High

578290

TTC3
E3 ubiquitin-protein ligase TTC3

1

4

High-throughput

0.541

High

578291

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.541

High

578306

ZBT44
Zinc finger and BTB domain-containing protein 44

1

6

High-throughput

0.541

High

578313

EGLN2
Prolyl hydroxylase EGLN2

1

1

High-throughput

0.541

High

578317

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.541

High

578320

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.541

High

578321

PPME1
Protein phosphatase methylesterase 1

1

1

High-throughput

0.541

High

578319

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

1

High-throughput

0.536

High

578322

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

578299

TWST1
Twist-related protein 1

1

16

Small-scale

0.534

High

578309

TWST2
Twist-related protein 2

1

14

Small-scale

0.534

High

429237

JUN
Transcription factor Jun

1

20

Small-scale

0.527

High

163374

GBRD
Gamma-aminobutyric acid receptor subunit delta

1

0

High-throughput

0.518

High

223595

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.518

High

533577

CLUS
Clusterin

1

0

High-throughput

0.518

High

578302

FOCAD
Focadhesin

1

0

High-throughput

0.518

High

578310

NDRG1
Protein NDRG1

1

0

High-throughput

0.518

High

578284

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.515

High

578288

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

578318

IMPCT
Protein IMPACT

1

0

High-throughput

0.513

High

578323

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.513

High

370536

FOS
Protein c-Fos

1

16

Small-scale

0.501

High

578315

SRA1
Steroid receptor RNA activator 1

1

1

Small-scale

0.501

High

578308

DMXL2
DmX-like protein 2

1

14

High-throughput

0.494

High

336061

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

0

High-throughput

0.486

High

507489

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

159495

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

3

High-throughput

0.479

High

172447

XPO1
Exportin-1

1

7

Small-scale

0.479

High

186692

P73
Tumor protein p73

1

5

Small-scale

0.479

High

278227

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.479

High

403794

GCR
Glucocorticoid receptor

1

13

Small-scale

0.479

High

578285

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.479

High

578287

EGR1
Early growth response protein 1

1

8

High-throughput

0.479

High

578294

EWS
RNA-binding protein EWS

1

8

High-throughput

0.479

High

578300

NCOA1
Nuclear receptor coactivator 1

1

19

Small-scale

0.479

High

578305

DET1
DET1 homolog

1

3

Small-scale

0.479

High

578314

GFI1
Zinc finger protein Gfi-1

1

2

Small-scale

0.479

High

578316

TLR9
Toll-like receptor 9

1

4

Small-scale

0.479

High

578324

NCOA3
Nuclear receptor coactivator 3

1

19

Small-scale

0.479

High

578289

SERPH
Serpin H1

1

8

High-throughput

0.470

High

578292

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.282

High

578304

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025