HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.906

The method score is based on:

Property Details
Experiments 10913276, 10940929, 17474147, 9020117
Identification Methods pull down, affinity chromatography technology, peptide array, fluorescence technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PH~PH, PH~RhoGEF, PH~SH3_1, RhoGEF~SH3_1
Common GO terms GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
and 1 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 1290
Hs

1 1333
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024