HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (EC 3.6.5.2) (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ank~Ras, Ank_2~Ras
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 2471
+	Hs
		988304 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		NOTC2_HUMAN (22-2471): 0: 1400: 100.00
+	Hs
		601251 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		NOTC2_HUMAN (22-2471): 0: 1400: 100.00
+	Hs
		953406 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		NOTC2_HUMAN (22-2471): 0: 1400: 100.00
+	Hs
		1015385 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		NOTC2_HUMAN (22-2471): 0: 1400: 100.00
+	Hs
		955084 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		NOTC2_HUMAN (22-2471): 0: 1400: 100.00
+	Hs
		988324 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		ANK3_HUMAN (1732-2286): 1.32e-110: 399: 15.11
+	Hs
		988289 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		ANK2_HUMAN (1719-2317): 5.19e-108: 390: 14.51
+	Hs
		1015396 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		ANK3_HUMAN (1732-2286): 1.32e-110: 399: 15.11
+	Hs
		955105 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		ANK3_HUMAN (1732-2286): 1.32e-110: 399: 15.11
+	Hs
		857404 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		580920 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		601206 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		857395 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		857413 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		857396 CDC42_HUMAN (1-192): 1.66e-78: 234: 68.75		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		988269 RAC1_HUMAN (1-192): 3.43e-86: 253: 92.19		JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04
+	Hs
		857398 RHOA_HUMAN (5-192): 1.59e-77: 231: 54.26		NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26
+	Hs
		580983 RAC2_HUMAN (1-192): 1.14e-83: 247: 100.00		JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04
+	Hs
		953388 RAC3_HUMAN (1-191): 4.97e-80: 238: 89.01		JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04
+	Hs
		1008013 RHOG_HUMAN (1-192): 5.1e-79: 235: 70.83		JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04