HitPredict

Interactor 1: PLCG1 (P19174)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11) (PLC-148) (Phosphoinositide phospholipase C-gamma-1) (Phospholipase C-II) (PLC-II) (Phospholipase C-gamma-1) (PLC-gamma-1)
Gene: PLCG1

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.891

Property	Details
Experiments	10092678, 26253177, 12074588, 35384245
Identification Methods	pull down, affinity chromatography technology, two hybrid, proximity labelling technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, LRR_8~SH2, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1290 Hs			1 822
+	Mm
		546302 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Rn
		499163 PLCG1_RAT (1-1290): 0: 1299: 96.90		NTRK2_RAT (1-822): 0: 622: 93.55
+	Hs
		581012 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		580926 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		580927 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		384239 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Mm
		1112476 PLCG1_MOUSE (1-1288): 0: 1302: 96.12		NTRK1_MOUSE (45-822): 2.04e-173: 521: 47.09
+	Hs
		507843 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		580923 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		FGFR2_HUMAN (120-821): 4.81e-164: 498: 23.04
+	Rn
		499160 PLCG1_RAT (1-1290): 0: 1299: 96.90		FGFR1_RAT (129-821): 8.2e-163: 495: 22.67
+	Hs
		434135 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		RET_HUMAN (436-820): 1.09e-115: 379: 33.00
+	Hs
		562650 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		507835 PLCG2_HUMAN (18-1287): 0: 1128: 49.45		FGFR1_HUMAN (180-821): 3.75e-164: 498: 23.77
+	Hs
		580989 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		DDR1_HUMAN (535-807): 1.28e-74: 263: 47.37
+	Hs
		411292 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		INSR_HUMAN (513-809): 2.11e-70: 254: 43.38
+	Hs
		581078 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44
+	Rn
		499158 PLCG1_RAT (1-1290): 0: 1299: 96.90		INSR_RAT (513-809): 7.79e-68: 247: 42.72
+	Hs
		580940 PLCG1_HUMAN (1-1290): 0: 1314: 100.00		LTK_HUMAN (506-808): 6.29e-61: 223: 38.07
+	Hs
		609614 PLCL2_HUMAN (840-1240): 4.61e-92: 324: 29.23		FGFR3_HUMAN (128-822): 1.4e-170: 514: 24.45
+	Hs
		961599 PLCB2_HUMAN (714-1264): 5.46e-89: 316: 21.99		ALK_HUMAN (513-799): 4.96e-64: 236: 41.44