HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: SET (Q01105)
Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)
Gene: SET

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28242625
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~NAP
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly GO:0042393 - histone binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 143 Hs			1 290
+	Hs
		277648 H2AY_HUMAN (1-142): 1.75e-61: 194: 60.69		SET_HUMAN (1-236): 1.98e-87: 264: 100.00
+	Hs
		419196 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		TSYL1_HUMAN (44-234): 1.34e-83: 259: 38.74
+	Hs
		591557 H2AX_HUMAN (1-143): 3.73e-74: 219: 100.00		NP1L1_HUMAN (2-278): 6.65e-74: 233: 18.41
+	Hs
		419060 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		TSYL5_HUMAN (2-257): 1.22e-80: 251: 32.69
+	Hs
		277732 H2AY_HUMAN (1-142): 1.75e-61: 194: 60.69		TSYL5_HUMAN (2-257): 1.22e-80: 251: 32.69
+	Hs
		419161 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		NP1L4_HUMAN (4-242): 2.1e-75: 236: 18.81
+	Hs
		502496 H2A1_HUMAN (1-129): 7.6e-66: 197: 91.47		NP1L4_HUMAN (4-242): 2.1e-75: 236: 18.81
+	Hs
		1162878 H2A2C_HUMAN (1-129): 5.12e-65: 195: 90.70		NP1L4_HUMAN (4-242): 2.1e-75: 236: 18.81
+	Hs
		936799 H2A2B_HUMAN (1-128): 3.45e-66: 198: 92.97		NP1L1_HUMAN (2-278): 6.65e-74: 233: 18.41
+	Hs
		418902 H2A1B_HUMAN (1-129): 8.38e-66: 197: 90.70		NP1L1_HUMAN (2-278): 6.65e-74: 233: 18.41
+	Hs
		502278 H2A1_HUMAN (1-129): 7.6e-66: 197: 91.47		NP1L1_HUMAN (2-278): 6.65e-74: 233: 18.41
+	Hs
		1030935 H2A2C_HUMAN (1-129): 5.12e-65: 195: 90.70		TSPY1_HUMAN (23-250): 1.5e-75: 234: 33.33
+	Hs
		936762 H2A2C_HUMAN (1-129): 5.12e-65: 195: 90.70		NP1L1_HUMAN (2-278): 6.65e-74: 233: 18.41
+	Hs
		277616 H2AY_HUMAN (1-142): 1.75e-61: 194: 60.69		NP1L1_HUMAN (2-278): 6.65e-74: 233: 18.41
+	Rn
		1194065 H2A3_RAT (1-129): 5.9e-66: 197: 91.47		TSPY1_RAT (6-237): 1.63e-71: 225: 30.17
+	Dm
		1014829 H2A_DROME (17-124): 3.84e-60: 183: 90.74		Q24150_DROME (18-238): 4.15e-66: 212: 20.54
+	Dm
		1014847 H2A_DROME (17-124): 3.84e-60: 183: 90.74		Q9W1G7_DROME (18-238): 3.69e-66: 212: 20.54
+	Sc
		419363 H2A1_YEAST (16-142): 1.37e-53: 166: 75.59		NAP1_YEAST (38-286): 1.23e-34: 131: 21.54
+	Sc
		419613 H2A2_YEAST (16-124): 4.63e-53: 165: 82.57		NAP1_YEAST (38-286): 1.23e-34: 131: 21.54