HitPredict

Interactor 1: PGFRA (P16234)
Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
Gene: PDGFRA

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1089 Hs			1 665
+	Hs
		484199 PGFRB_HUMAN (29-1089): 0: 641: 43.24		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		532098 KIT_HUMAN (18-978): 0: 559: 33.20		SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00
+	Hs
		593330 PGFRA_HUMAN (1-1089): 0: 809: 100.00		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		484098 PGFRB_HUMAN (29-1089): 0: 641: 43.24		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		484041 PGFRB_HUMAN (29-1089): 0: 641: 43.24		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Hs
		222004 PGFRB_HUMAN (29-1089): 0: 641: 43.24		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Hs
		484038 PGFRB_HUMAN (29-1089): 0: 641: 43.24		VAV_HUMAN (84-158): 6.3e-13: 74.3: 28.95
+	Mm
		431458 KIT_MOUSE (18-996): 0: 569: 33.20		GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37
+	Hs
		532067 KIT_HUMAN (18-978): 0: 559: 33.20		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		532039 KIT_HUMAN (18-978): 0: 559: 33.20		NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62
+	Mm
		313427 KIT_MOUSE (18-996): 0: 569: 33.20		GRAP2_MOUSE (1-58): 1.39e-16: 83.2: 29.31
+	Mm
		431453 KIT_MOUSE (18-996): 0: 569: 33.20		VAV_MOUSE (4-55): 2.23e-14: 79: 41.51
+	Hs
		222007 KIT_HUMAN (18-978): 0: 559: 33.20		NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24
+	Hs
		292803 KIT_HUMAN (18-978): 0: 559: 33.20		GRAP2_HUMAN (1-58): 2.52e-17: 85.5: 31.03
+	Hs
		787001 FLT3_HUMAN (37-979): 1.02e-155: 490: 29.76		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Ce
		711452 EGL15_CAEEL (5-1072): 1.22e-151: 480: 16.68		SEM5_CAEEL (4-70): 2.01e-20: 92.7: 35.82
+	Hs
		987593 MERTK_HUMAN (121-1073): 1.67e-130: 423: 17.11		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37
+	Hs
		584528 MERTK_HUMAN (121-1073): 1.67e-130: 423: 17.11		VAV_HUMAN (84-158): 6.3e-13: 74.3: 28.95
+	Mm
		778129 VGFR1_MOUSE (8-616): 3.98e-57: 218: 20.34		CD2AP_MOUSE (1-663): 1.87e-80: 269: 31.53
+	Hs
		650120 FGFR3_HUMAN (745-969): 1.5e-76: 271: 40.74		GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37