HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: FLNC (Q14315)
Filamin-C (FLN-C) (FLNc) (ABP-280-like protein) (ABP-L) (Actin-binding-like protein) (Filamin-2) (Gamma-filamin)
Gene: FLNC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 377 Hs			1 2725
+	Hs
		440557 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		FLNC_HUMAN (1-2725): 0: 2518: 100.00
+	Hs
		699747 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		FLNC_HUMAN (1-2725): 0: 2518: 100.00
+	Hs
		278006 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		FLNB_HUMAN (146-2725): 0: 1196: 35.23
+	Hs
		320208 SRBS2_HUMAN (64-287): 7.79e-24: 105: 18.26		FLNA_HUMAN (147-2725): 0: 1228: 35.27
+	Hs
		440361 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		FLNA_HUMAN (147-2725): 0: 1228: 35.27
+	Hs
		637356 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		FLNA_HUMAN (147-2725): 0: 1228: 35.27
+	Hs
		637439 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		FLNA_HUMAN (147-2725): 0: 1228: 35.27
+	Hs
		278020 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		FLNB_HUMAN (146-2725): 0: 1196: 35.23
+	Hs
		278058 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		FLNB_HUMAN (146-2725): 0: 1196: 35.23
+	Mm
		1190854 SRBS2_MOUSE (46-288): 7.42e-25: 108: 18.85		ACTN1_MOUSE (13-382): 3.13e-122: 412: 26.30
+	Hs
		320206 SRBS2_HUMAN (64-287): 7.79e-24: 105: 18.26		ACTN1_HUMAN (13-382): 4.65e-121: 409: 26.04
+	Hs
		224564 SRBS2_HUMAN (64-287): 7.79e-24: 105: 18.26		ACTN4_HUMAN (16-387): 1.42e-119: 405: 26.68
+	Ce
		91961 Q95PW9_CAEEL (1-376): 7.39e-71: 228: 38.69		D0IMZ5_CAEEL (1338-2724): 2.73e-74: 279: 16.77
+	Ce
		91973 Q95PW9_CAEEL (1-376): 7.39e-71: 228: 38.69		D0IMZ6_CAEEL (810-1629): 3.74e-75: 271: 25.55
+	Hs
		555659 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		ACTN1_HUMAN (13-382): 4.65e-121: 409: 26.04
+	Hs
		224684 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		ACTN4_HUMAN (16-387): 1.42e-119: 405: 26.68
+	Hs
		136370 P85B_HUMAN (250-376): 7.23e-21: 96.4: 24.03		SPTB2_HUMAN (26-266): 1.26e-100: 365: 38.12
+	Hs
		987544 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		PGBM_HUMAN (1306-2725): 9.97e-72: 271: 11.81
+	Hs
		388896 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		FINC_HUMAN (1545-2724): 4.55e-64: 246: 13.76
+	Hs
		389258 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		FINC_HUMAN (1545-2724): 4.55e-64: 246: 13.76