HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: RIMS2 (Q9UQ26)
Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3)
Gene: RIMS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2, C2~SH3_1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1411
+	Hs
		440791 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		RIMS2_HUMAN (1-1411): 0: 871: 100.00
+	Hs
		988037 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		RIMS2_HUMAN (1-1411): 0: 871: 100.00
+	Hs
		143991 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		P3C2B_HUMAN (738-938): 3.6e-41: 168: 22.22
+	Hs
		594037 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		RIMS1_HUMAN (917-1386): 1.71e-12: 74.6: 11.09
+	Hs
		143995 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		P3C2B_HUMAN (738-938): 3.6e-41: 168: 22.22
+	Mm
		98285 ITSN1_MOUSE (5-66): 4.45e-15: 79.2: 25.81		E9QAN8_MOUSE (738-937): 6.03e-42: 171: 22.33
+	Hs
		144005 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		P3C2B_HUMAN (738-938): 3.6e-41: 168: 22.22
+	Hs
		144011 ITSN1_HUMAN (1-66): 2.26e-15: 80: 25.76		P3C2B_HUMAN (738-938): 3.6e-41: 168: 22.22
+	Hs
		144027 ITSN2_HUMAN (7-85): 2.53e-12: 70.6: 24.05		P3C2B_HUMAN (738-938): 3.6e-41: 168: 22.22
+	Hs
		463124 YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27		SYT6_HUMAN (503-960): 3.88e-42: 164: 16.27
+	Hs
		1384309 SH3K1_HUMAN (56-207): 4.07e-09: 60.1: 17.53		RP3A_HUMAN (522-1036): 4.05e-31: 133: 13.35
+	Hs
		440614 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		RIMS1_HUMAN (917-1386): 1.71e-12: 74.6: 11.09
+	Hs
		297354 ITSN1_HUMAN (1-66): 2.26e-15: 80: 25.76		DYSF_HUMAN (701-1072): 2.09e-18: 94.2: 15.93
+	Hs
		463209 YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27		SYT3_HUMAN (807-927): 1.66e-21: 102: 24.79
+	Hs
		840978 ABL2_HUMAN (197-356): 1.15e-15: 80.9: 33.95		NED4L_HUMAN (1258-1371): 3.66e-15: 83.2: 25.21
+	Hs
		987743 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		RIMS1_HUMAN (917-1386): 1.71e-12: 74.6: 11.09
+	Mm
		431353 SRC_MOUSE (5-201): 8.43e-15: 77.8: 17.41		P3C2A_MOUSE (810-930): 6.18e-11: 69.7: 35.25