HitPredict

Interactor 1: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Interactor 2: RIMS1 (Q86UR5)
Regulating synaptic membrane exocytosis protein 1 (Rab-3-interacting molecule 1) (RIM 1) (Rab-3-interacting protein 2)
Gene: RIMS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C2~SH2, C2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 377 Hs			1 1692
+	Hs
		440614 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		RIMS1_HUMAN (1-1692): 0: 976: 100.00
+	Hs
		987743 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		RIMS1_HUMAN (1-1692): 0: 976: 100.00
+	Hs
		143991 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		P3C2B_HUMAN (675-875): 8.83e-41: 167: 24.02
+	Hs
		594142 NCK1_HUMAN (1-377): 2.37e-99: 301: 100.00		RIMS2_HUMAN (275-869): 8.47e-17: 89.3: 13.86
+	Hs
		463124 YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27		SYT6_HUMAN (435-887): 1.62e-55: 204: 15.34
+	Hs
		143995 P85A_HUMAN (241-376): 5.42e-23: 102: 19.57		P3C2B_HUMAN (675-875): 8.83e-41: 167: 24.02
+	Hs
		144005 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		P3C2B_HUMAN (675-875): 8.83e-41: 167: 24.02
+	Hs
		144011 ITSN1_HUMAN (1-66): 2.26e-15: 80: 25.76		P3C2B_HUMAN (675-875): 8.83e-41: 167: 24.02
+	Mm
		98285 ITSN1_MOUSE (5-66): 4.45e-15: 79.2: 25.81		E9QAN8_MOUSE (675-874): 1.26e-40: 167: 24.54
+	Hs
		144027 ITSN2_HUMAN (7-85): 2.53e-12: 70.6: 24.05		P3C2B_HUMAN (675-875): 8.83e-41: 167: 24.02
+	Mm
		632514 GRB2_MOUSE (3-61): 2.57e-17: 81.8: 28.81		KPCA_MOUSE (744-879): 6.04e-38: 155: 25.90
+	Hs
		1384309 SH3K1_HUMAN (56-207): 4.07e-09: 60.1: 17.53		RP3A_HUMAN (1167-1680): 9.15e-36: 148: 11.56
+	Hs
		840978 ABL2_HUMAN (197-356): 1.15e-15: 80.9: 33.95		NED4L_HUMAN (1535-1687): 2.44e-28: 126: 21.12
+	Hs
		440791 FYN_HUMAN (7-164): 5.43e-24: 105: 17.50		RIMS2_HUMAN (275-869): 8.47e-17: 89.3: 13.86
+	Mm
		431353 SRC_MOUSE (5-201): 8.43e-15: 77.8: 17.41		P3C2A_MOUSE (1526-1664): 3.36e-23: 110: 26.67
+	Hs
		988037 GRB2_HUMAN (3-61): 2.31e-17: 82.1: 28.81		RIMS2_HUMAN (275-869): 8.47e-17: 89.3: 13.86
+	Hs
		297354 ITSN1_HUMAN (1-66): 2.26e-15: 80: 25.76		DYSF_HUMAN (1553-1686): 4.37e-15: 83.5: 20.00
+	Hs
		463209 YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27		SYT3_HUMAN (744-864): 1.77e-09: 64.7: 36.29