HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37689310
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043433 - negative regulation of DNA-binding transcription factor activity
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 605
+	Hs
		598367 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		598260 FLNA_HUMAN (1-2647): 0: 2776: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		597996 FLNA_HUMAN (1-2647): 0: 2776: 100.00		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		598209 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WDR5B_HUMAN (409-604): 7.04e-48: 172: 29.27
+	Hs
		598345 FLNA_HUMAN (1-2647): 0: 2776: 100.00		NLE1_HUMAN (33-408): 1.35e-41: 159: 13.21
+	Hs
		598040 FLNA_HUMAN (1-2647): 0: 2776: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		598240 FLNA_HUMAN (1-2647): 0: 2776: 100.00		POC1B_HUMAN (189-438): 4.67e-35: 140: 13.27
+	Hs
		261236 FLNB_HUMAN (28-2647): 0: 2710: 69.63		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		1052959 FLNC_HUMAN (32-2647): 0: 1432: 35.96		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		903137 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		957555 PGBM_HUMAN (181-1251): 3.53e-32: 140: 12.81		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71