HitPredict

Interactor 1: TA2R (P21731)
Thromboxane A2 receptor (TXA2-R) (Prostanoid TP receptor)
Gene: TBXA2R

Interactor 2: PI2R (P43119)
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
Gene: PTGIR

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	15471868, 23493750, 20522800
Identification Methods	affinity chromatography technology, fluorescent resonance energy transfer
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	7tm_1~7tm_1
Common GO terms	GO:0005085 - guanyl-nucleotide exchange factor activity GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0007189 - adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007204 - positive regulation of cytosolic calcium ion concentration
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 343 Hs			1 386
+	Hs
		600862 TA2R_HUMAN (1-343): 3.98e-62: 203: 100.00		TA2R_HUMAN (7-325): 1.04e-87: 270: 31.44
+	Hs
		793172 PI2R_HUMAN (18-342): 3.37e-70: 225: 30.33		PI2R_HUMAN (1-386): 1.72e-74: 237: 100.00
+	Hs
		428907 TSHR_HUMAN (12-338): 9.63e-63: 214: 17.27		ADRB2_HUMAN (5-376): 1.54e-72: 233: 14.29
+	Hs
		723007 ADA1B_HUMAN (2-327): 4.68e-64: 213: 13.35		ADA1B_HUMAN (2-384): 4.8e-71: 232: 15.33
+	Hs
		428881 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		ADRB2_HUMAN (5-376): 1.54e-72: 233: 14.29
+	Hs
		428883 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		ADRB1_HUMAN (2-380): 3.48e-66: 219: 13.65
+	Hs
		626678 ADA1B_HUMAN (2-327): 4.68e-64: 213: 13.35		ADA1D_HUMAN (16-383): 2.1e-63: 214: 14.95
+	Hs
		680101 SSR5_HUMAN (35-338): 8.95e-63: 205: 17.26		SSR4_HUMAN (19-373): 4.05e-68: 221: 17.04
+	Hs
		722929 ADA1B_HUMAN (2-327): 4.68e-64: 213: 13.35		ADA1A_HUMAN (2-321): 1.03e-63: 212: 16.15
+	Hs
		676815 SSR5_HUMAN (35-338): 8.95e-63: 205: 17.26		SSR2_HUMAN (2-350): 4.19e-67: 218: 13.84
+	Mm
		578598 ADRB2_MOUSE (1-332): 5.92e-64: 210: 13.09		ADRB1_MOUSE (30-378): 2.94e-63: 211: 14.32
+	Hs
		722921 SSR5_HUMAN (35-338): 8.95e-63: 205: 17.26		SSR5_HUMAN (24-336): 1.84e-66: 216: 17.61
+	Hs
		1040070 MTR1L_HUMAN (14-324): 2.43e-61: 208: 13.83		MTR1L_HUMAN (4-378): 1.43e-62: 212: 14.40
+	Hs
		626674 ADA1D_HUMAN (16-319): 1.75e-60: 205: 15.23		ADA1D_HUMAN (16-383): 2.1e-63: 214: 14.95
+	Hs
		676800 SSR5_HUMAN (35-338): 8.95e-63: 205: 17.26		SSR1_HUMAN (12-308): 1.03e-63: 210: 14.38
+	Hs
		722928 ADA1A_HUMAN (5-336): 3.7e-60: 201: 12.16		ADA1A_HUMAN (2-321): 1.03e-63: 212: 16.15
+	Hs
		825693 MTR1L_HUMAN (14-324): 2.43e-61: 208: 13.83		MTR1B_HUMAN (7-336): 2.38e-58: 195: 20.48
+	Hs
		428939 ADRB2_HUMAN (1-331): 4.89e-64: 210: 12.57		PE2R1_HUMAN (12-299): 3.58e-40: 148: 26.65