Interactor 1: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.954

The method score is based on:

Property Details
Experiments 8375396, 31980649, 36508083, 19211765, 10398585, 11078718, 10849009
Identification Methods enzymatic study, affinity chromatography technology, in-gel kinase assay, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~C1_1, C1_1~C2, C1_1~Pkinase, C1_1~Pkinase_C, C2~C2, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms GO:0000302 - response to reactive oxygen species
GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0002159 - desmosome assembly
GO:0004672 - protein kinase activity
and 62 others

more...

Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 672
Hs

1 672
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Service provided by Combinatics, Japan

Last updated: 11Aug2025