HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33391517, 11697890, 36931259
Identification Methods	affinity chromatography technology, cross-linking study, biochemical
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 906 Hs			1 248
+	Hs
		610330 CBL_HUMAN (1-906): 0: 917: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		610341 CBL_HUMAN (1-906): 0: 917: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Mm
		610571 CBL_MOUSE (1-906): 0: 888: 91.59		1433E_MOUSE (2-246): 4.41e-146: 410: 60.41
+	Mm
		610575 CBL_MOUSE (1-906): 0: 888: 91.59		1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96
+	Hs
		610234 CBL_HUMAN (1-906): 0: 917: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		610254 CBL_HUMAN (1-906): 0: 917: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		610327 CBL_HUMAN (1-906): 0: 917: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		610365 CBL_HUMAN (1-906): 0: 917: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Mm
		610576 CBL_MOUSE (1-906): 0: 888: 91.59		1433T_MOUSE (1-238): 7.63e-107: 310: 71.43
+	Mm
		610638 CBL_MOUSE (1-906): 0: 888: 91.59		1433B_MOUSE (1-239): 3.73e-99: 290: 68.62
+	Mm
		610568 CBL_MOUSE (1-906): 0: 888: 91.59		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Mm
		610578 CBL_MOUSE (1-906): 0: 888: 91.59		1433F_MOUSE (2-242): 1.72e-96: 284: 64.20
+	Ce
		1093846 Q6ABG8_CAEEL (43-510): 0: 662: 48.24		14332_CAEEL (3-238): 1.01e-96: 284: 66.95
+	Ce
		1090465 Q19019_CAEEL (49-546): 0: 639: 44.12		14332_CAEEL (3-238): 1.01e-96: 284: 66.95
+	Hs
		297821 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		297824 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		297815 K0754_HUMAN (395-794): 1.98e-40: 164: 11.17		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		647025 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683472 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		904746 OTOG_HUMAN (405-893): 1.88e-23: 109: 12.85		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16