HitPredict

Interactor 1: PSD10 (O75832)
26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin) (p28(GANK))
Gene: PSMD10

Interactor 2: PRS6A (P17980)
26S proteasome regulatory subunit 6A (26S proteasome AAA-ATPase subunit RPT5) (Proteasome 26S subunit ATPase 3) (Proteasome subunit P50) (Tat-binding protein 1) (TBP-1)
Gene: PSMC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	1.00	0.941

Property	Details
Experiments	17353931, 33961781, 26186194, 28514442, 19490896, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA_lid_3~Ank, AAA_lid_3~Ank_2
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 226 Hs			1 439
+	Hs
		295482 PSD10_HUMAN (1-226): 2.52e-72: 221: 100.00		PRS4_HUMAN (32-433): 9.24e-134: 393: 43.60
+	Hs
		295462 PSD10_HUMAN (1-226): 2.52e-72: 221: 100.00		PRS7_HUMAN (21-433): 3.78e-124: 369: 37.35
+	Hs
		295483 PSD10_HUMAN (1-226): 2.52e-72: 221: 100.00		PRS8_HUMAN (65-437): 1.52e-124: 369: 44.39
+	Hs
		295468 PSD10_HUMAN (1-226): 2.52e-72: 221: 100.00		PRS6B_HUMAN (8-438): 2.68e-121: 361: 37.59
+	Hs
		778782 Q9H4D1_HUMAN (10-224): 4.44e-56: 192: 26.39		PRS7_HUMAN (21-433): 3.78e-124: 369: 37.35
+	Mm
		932175 PSD10_MOUSE (48-224): 5.56e-50: 164: 29.78		PRS6B_MOUSE (8-438): 2.65e-120: 358: 37.59
+	Hs
		610492 RAI14_HUMAN (1-109): 1.7e-20: 91.2: 23.85		PRS6A_HUMAN (1-439): 2.6e-139: 408: 100.00
+	Hs
		934478 ANK2_HUMAN (4-224): 3.26e-66: 222: 28.30		TERA_HUMAN (167-434): 7.33e-79: 262: 35.09
+	Hs
		934346 RIPK4_HUMAN (10-224): 2.2e-56: 193: 26.39		TERA_HUMAN (167-434): 7.33e-79: 262: 35.09
+	Hs
		935134 Q9H4D1_HUMAN (10-224): 4.44e-56: 192: 26.39		TERA_HUMAN (167-434): 7.33e-79: 262: 35.09
+	Hs
		968989 AN36B_HUMAN (9-96): 2.56e-11: 64.6: 23.86		PRS8_HUMAN (65-437): 1.52e-124: 369: 44.39
+	Hs
		943993 RIPK4_HUMAN (10-224): 2.2e-56: 193: 26.39		AFG2A_HUMAN (182-435): 2.26e-70: 240: 34.94
+	At
		1300276 Q8GZ22_ARATH (72-212): 2.56e-10: 60.5: 31.94		PRS6B_ARATH (38-438): 5.45e-126: 372: 38.40
+	Hs
		1333197 Q9H4D1_HUMAN (10-224): 4.44e-56: 192: 26.39		AFG2A_HUMAN (182-435): 2.26e-70: 240: 34.94
+	Sc
		750730 PSD10_YEAST (76-219): 1.92e-09: 57.8: 32.90		PRS6A_YEAST (26-439): 1.37e-120: 359: 69.05
+	Hs
		935277 KDIS_HUMAN (1-142): 1.41e-33: 129: 25.52		TERA_HUMAN (167-434): 7.33e-79: 262: 35.09
+	Sc
		822416 PSD10_YEAST (76-219): 1.92e-09: 57.8: 32.90		PRS4_YEAST (122-431): 4.89e-102: 312: 50.65
+	Hs
		934835 ANKH1_HUMAN (1-61): 1.43e-09: 59.6: 16.39		TERA_HUMAN (167-434): 7.33e-79: 262: 35.09