HitPredict

Interactor 1: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: K22E (P35908)
Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (CK-2e) (Epithelial keratin-2e) (Keratin-2 epidermis) (Keratin-2e) (K2e) (Type-II keratin Kb2)
Gene: KRT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 906 Hs			1 639
+	Hs
		380560 CBL_HUMAN (1-906): 0: 917: 100.00		K2C1_HUMAN (143-509): 1.63e-112: 353: 71.94
+	Hs
		610513 CBL_HUMAN (1-906): 0: 917: 100.00		KRT84_HUMAN (5-589): 2.17e-100: 320: 44.20
+	Hs
		531534 CBL_HUMAN (1-906): 0: 917: 100.00		K2C5_HUMAN (1-494): 7.49e-82: 271: 61.48
+	Hs
		380445 CBL_HUMAN (1-906): 0: 917: 100.00		K2C6B_HUMAN (5-510): 8.35e-82: 270: 61.22
+	Hs
		610295 CBL_HUMAN (1-906): 0: 917: 100.00		K2C6C_HUMAN (5-510): 2.02e-81: 269: 61.61
+	Hs
		610433 CBL_HUMAN (1-906): 0: 917: 100.00		K2C79_HUMAN (32-568): 4.69e-80: 264: 55.35
+	Hs
		359466 CBL_HUMAN (1-906): 0: 917: 100.00		K2C6A_HUMAN (5-510): 8.33e-78: 259: 61.22
+	Hs
		517738 CBL_HUMAN (1-906): 0: 917: 100.00		K2C3_HUMAN (27-494): 2.18e-66: 230: 64.32
+	Hs
		203197 SYNJ1_HUMAN (542-897): 2.72e-14: 79.6: 10.22		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33
+	Hs
		409194 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		K2C8_HUMAN (150-535): 1.29e-143: 427: 59.33
+	Hs
		580149 ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25		K2C4_HUMAN (11-509): 2.24e-73: 246: 59.72