HitPredict

Interactor 1: CBL (P22682)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Interactor 2: SLAP1 (Q60898)
Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (mSLAP)
Gene: Sla

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	12024036
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Mm			1 281
+	Mm
		403415 CBL_MOUSE (1-913): 0: 923: 100.00		SRC_MOUSE (2-280): 4.85e-99: 301: 25.90
+	Mm
		536206 CBL_MOUSE (1-913): 0: 923: 100.00		FGR_MOUSE (5-280): 5.51e-99: 301: 24.34
+	Mm
		610554 CBL_MOUSE (1-913): 0: 923: 100.00		FYN_MOUSE (9-280): 5.05e-98: 299: 26.25
+	Mm
		435877 CBL_MOUSE (1-913): 0: 923: 100.00		HCK_MOUSE (2-280): 2.92e-95: 291: 26.80
+	Mm
		411917 CBL_MOUSE (1-913): 0: 923: 100.00		LCK_MOUSE (2-280): 8.49e-95: 290: 26.32
+	Mm
		610545 CBL_MOUSE (1-913): 0: 923: 100.00		LYN_MOUSE (5-280): 1.65e-94: 289: 25.50
+	Hs
		433254 CBL_HUMAN (1-913): 0: 894: 91.05		YES_HUMAN (17-280): 1.71e-99: 303: 26.55
+	Hs
		454799 CBL_HUMAN (1-913): 0: 894: 91.05		FGR_HUMAN (2-280): 1.77e-99: 302: 24.76
+	Hs
		412013 CBL_HUMAN (1-913): 0: 894: 91.05		FYN_HUMAN (9-280): 1.55e-97: 298: 25.91
+	Hs
		442780 CBL_HUMAN (1-913): 0: 894: 91.05		HCK_HUMAN (2-280): 6.9e-97: 296: 27.04
+	Hs
		433577 CBL_HUMAN (1-913): 0: 894: 91.05		LYN_HUMAN (5-280): 1.96e-94: 289: 25.50
+	Hs
		411595 CBL_HUMAN (1-913): 0: 894: 91.05		LCK_HUMAN (2-280): 2.55e-94: 288: 25.66
+	Mm
		337618 CBL_MOUSE (1-913): 0: 923: 100.00		ABL1_MOUSE (2-267): 1.34e-70: 237: 20.28
+	Mm
		610586 CBL_MOUSE (1-913): 0: 923: 100.00		ITK_MOUSE (3-279): 8.95e-73: 236: 18.33
+	Mm
		610555 CBL_MOUSE (1-913): 0: 923: 100.00		CSK_MOUSE (20-274): 5.23e-72: 229: 19.01
+	Mm
		610629 CBL_MOUSE (1-913): 0: 923: 100.00		SLAP2_MOUSE (10-247): 3.22e-67: 211: 43.85
+	Hs
		337348 CBL_HUMAN (1-913): 0: 894: 91.05		ABL1_HUMAN (2-267): 9.62e-71: 237: 20.28
+	Mm
		610598 CBL_MOUSE (1-913): 0: 923: 100.00		GRB2_MOUSE (28-164): 4.43e-57: 184: 30.00
+	Hs
		69201 CBL_HUMAN (1-913): 0: 894: 91.05		A9UF07_HUMAN (13-248): 5.53e-56: 196: 24.62
+	Mm
		292681 CBL_MOUSE (1-913): 0: 923: 100.00		GRAP2_MOUSE (43-160): 2.27e-11: 65.1: 36.13