HitPredict - High confidence protein-protein interactions

Interactor 1: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Interactor 2: ATF3 (P18847)
Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3)
Gene: ATF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.807

Property	Details
Experiments	18255255, 23661758
Identification Methods	two hybrid, pull down, fluorescent resonance energy transfer
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_1
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000976 - transcription cis-regulatory region binding GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding and 28 others more... GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005794 - Golgi apparatus GO:0005813 - centrosome GO:0006094 - gluconeogenesis GO:0006357 - regulation of transcription by RNA polymerase II GO:0008284 - positive regulation of cell population proliferation GO:0010628 - positive regulation of gene expression GO:0016604 - nuclear body GO:0030968 - endoplasmic reticulum unfolded protein response GO:0034198 - cellular response to amino acid starvation GO:0034976 - response to endoplasmic reticulum stress GO:0035914 - skeletal muscle cell differentiation GO:0036064 - ciliary basal body GO:0042803 - protein homodimerization activity GO:0043231 - intracellular membrane-bounded organelle GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0070373 - negative regulation of ERK1 and ERK2 cascade GO:0090575 - RNA polymerase II transcription regulator complex GO:1903984 - positive regulation of TRAIL-activated apoptotic signaling pathway GO:1990622 - CHOP-ATF3 complex GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1	181
Hs

1	181

Service provided by Combinatics, Japan

Last updated: 11Aug2025