HitPredict - High confidence protein-protein interactions

Interactor 1: GA45A (P24522)
Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)
Gene: GADD45A

Interactor 2: GA45A (P24522)
Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)
Gene: GADD45A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.812

Property	Details
Experiments	11498536, 22058036
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ribosomal_L7Ae~Ribosomal_L7Ae
Common GO terms	GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 20 others more... GO:0006281 - DNA repair GO:0006915 - apoptotic process GO:0007098 - centrosome cycle GO:0016525 - negative regulation of angiogenesis GO:0016607 - nuclear speck GO:0019900 - kinase binding GO:0033140 - negative regulation of peptidyl-serine phosphorylation of STAT protein GO:0042770 - signal transduction in response to DNA damage GO:0042803 - protein homodimerization activity GO:0043065 - positive regulation of apoptotic process GO:0043537 - negative regulation of blood vessel endothelial cell migration GO:0046330 - positive regulation of JNK cascade GO:0046982 - protein heterodimerization activity GO:0051726 - regulation of cell cycle GO:0071260 - cellular response to mechanical stimulus GO:0071479 - cellular response to ionizing radiation GO:0071901 - negative regulation of protein serine/threonine kinase activity GO:1900745 - positive regulation of p38MAPK cascade GO:1990841 - promoter-specific chromatin binding GO:2000379 - positive regulation of reactive oxygen species metabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	165
Hs

1	165

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Last updated: 15 Jul 2024