HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: CCDC6 (Q16204)
Coiled-coil domain-containing protein 6 (Papillary thyroid carcinoma-encoded protein) (Protein H4)
Gene: CCDC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 33961781, 38580884
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2843 Hs			1 474
+	Hs
		626183 APC_HUMAN (1-2843): 0: 1316: 100.00		TAXB1_HUMAN (59-365): 6.01e-28: 119: 20.46
+	Hs
		626129 APC_HUMAN (1-2843): 0: 1316: 100.00		DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02
+	Hs
		626064 APC_HUMAN (1-2843): 0: 1316: 100.00		MYH11_HUMAN (54-323): 1.64e-09: 62.6: 17.07
+	Hs
		626062 APC_HUMAN (1-2843): 0: 1316: 100.00		MYH10_HUMAN (2-333): 9.28e-09: 60.4: 10.39
+	Hs
		653974 MAP4_HUMAN (2119-2724): 1.19e-29: 131: 15.90		DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02
+	Hs
		1051385 TITIN_HUMAN (717-2430): 7.06e-29: 130: 7.55		DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02
+	Hs
		1056882 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		TAXB1_HUMAN (59-365): 6.01e-28: 119: 20.46
+	Hs
		149429 SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96		CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78
+	Hs
		1068702 SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96		PLEC_HUMAN (67-346): 2.74e-09: 61.9: 11.79
+	Hs
		944678 MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68		DCTN1_HUMAN (2-361): 1.64e-21: 100: 14.02
+	Hs
		148818 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78
+	Hs
		148524 PRC2A_HUMAN (951-2843): 2.17e-19: 98.6: 7.24		CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78
+	Hs
		1300969 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		DAPLE_HUMAN (52-339): 4.11e-09: 61.2: 16.88
+	Hs
		944680 MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68		PLEC_HUMAN (67-346): 2.74e-09: 61.9: 11.79
+	Hs
		149481 PCLO_HUMAN (733-2558): 8.98e-13: 77.2: 7.95		CTRO_HUMAN (50-352): 1.81e-09: 62.3: 11.78
+	Hs
		724893 MICA3_HUMAN (1200-1800): 2.91e-09: 65.2: 13.62		MYH9_HUMAN (4-401): 5.49e-12: 70.4: 11.78
+	Hs
		1186077 MICA3_HUMAN (1200-1800): 2.91e-09: 65.2: 13.62		MY18A_HUMAN (62-328): 1.49e-10: 65.8: 15.87