HitPredict

Interactor 1: PSA1 (P21243)
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
Gene: SCL1

Interactor 2: PSA2 (P23639)
Proteasome subunit alpha type-2 (Macropain subunit Y7) (Multicatalytic endopeptidase complex subunit Y7) (Proteasome component Y7) (Proteinase YSCE subunit 7)
Gene: PRE8

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.977

The method score is based on:

Property Details
Experiments 11805826, 16429126, 32868373, 31848235, 22940862, 14759368, 16554755, 18467557, 37968396, 31851481, 15253422
Identification Methods tandem affinity purification, affinity chromatography technology, cross-linking study, protein complementation assay, anti tag coimmunoprecipitation, dihydrofolate reductase reconstruction
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 252
Sc

1 250
+ Zm
+ Dm
+ Sp
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sc
+ Sp

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Last updated: 11Aug2025