Protein: PSA1
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)

Gene: PSA1, SCL1
Organism: Saccharomyces cerevisiae S288C
Interactions: 93
UniProt ID: P21243

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0010499 - proteasomal ubiquitin-independent protein catabolic process
GO:0019773 - proteasome core complex, alpha-subunit complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

636532

PSA7
Probable proteasome subunit alpha type-7

12

19

Small-scale

0.979

High

636622

PSB4
Proteasome subunit beta type-4

13

20

Small-scale

0.979

High

636626

PSA2
Proteasome subunit alpha type-2

11

17

Small-scale

0.977

High

636637

PSB5
Proteasome subunit beta type-5

7

20

Small-scale

0.962

High

636669

PSA4
Proteasome subunit alpha type-4

7

20

Small-scale

0.962

High

636668

PSA6
Proteasome subunit alpha type-6

6

20

Small-scale

0.943

High

636654

UMP1
Proteasome maturation factor UMP1

6

1

Small-scale

0.941

High

636625

PSA3
Proteasome subunit alpha type-3

5

20

Small-scale

0.922

High

636638

PSB7
Proteasome subunit beta type-7

5

20

High-throughput

0.922

High

636656

PSB1
Proteasome subunit beta type-1

5

20

High-throughput

0.922

High

636696

RPN5
26S proteasome regulatory subunit RPN5

5

19

Small-scale

0.919

High

636630

PSB3
Proteasome subunit beta type-3

4

20

High-throughput

0.896

High

636673

BLM10
Proteasome activator BLM10

4

7

Small-scale

0.890

High

636645

PRS6A
26S proteasome regulatory subunit 6A

4

20

Small-scale

0.873

High

636627

PSB6
Proteasome subunit beta type-6

3

20

High-throughput

0.839

High

636628

PSB2
Proteasome subunit beta type-2

2

20

High-throughput

0.776

High

636640

PSA5
Proteasome subunit alpha type-5

2

19

High-throughput

0.776

High

636674

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

12

20

Small-scale

0.755

High

636621

PSA1
Proteasome subunit alpha type-1

2

19

High-throughput

0.754

High

636646

PRS6B
26S proteasome regulatory subunit 6B homolog

2

20

High-throughput

0.754

High

636647

PRS7
26S proteasome regulatory subunit 7 homolog

2

20

Small-scale

0.754

High

636678

PRS10
26S proteasome subunit RPT4

2

20

High-throughput

0.754

High

636698

RPN6
26S proteasome regulatory subunit RPN6

2

20

High-throughput

0.754

High

636695

POC4
Proteasome chaperone 4

1

1

Small-scale

0.665

High

636662

RPN10
26S proteasome regulatory subunit RPN10

3

10

High-throughput

0.662

High

636643

RPN2
26S proteasome regulatory subunit RPN2

3

20

Small-scale

0.660

High

636639

IMB3
Importin subunit beta-3

2

1

High-throughput

0.621

High

636633

CDC48
Cell division control protein 48

1

12

High-throughput

0.618

High

636650

POC2
Proteasome assembly chaperone 2

1

1

High-throughput

0.618

High

636670

PRS4
26S proteasome regulatory subunit 4 homolog

1

20

High-throughput

0.618

High

636682

PRS8
26S proteasome regulatory subunit 8 homolog

1

20

High-throughput

0.618

High

636629

SIS1
Protein SIS1

2

6

High-throughput

0.601

High

636691

POC3
Proteasome chaperone 3

1

0

Small-scale

0.586

High

636642

RPN12
26S proteasome regulatory subunit RPN12

2

4

High-throughput

0.584

High

636657

ECM29
Proteasome component ECM29

2

11

High-throughput

0.584

High

636658

RPN1
26S proteasome regulatory subunit RPN1

2

20

Small-scale

0.584

High

619399

MED14
Mediator of RNA polymerase II transcription subunit 14

2

0

High-throughput

0.563

High

636632

FUB1
Silencing boundary-establishment protein FUB1

1

1

High-throughput

0.553

High

636687

POC1
Proteasome chaperone 1

1

1

High-throughput

0.553

High

636667

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

636631

PWP2
Periodic tryptophan protein 2

2

2

High-throughput

0.537

High

636624

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

636659

CIC1
Proteasome-interacting protein CIC1

1

0

Small-scale

0.513

High

636649

NOT4
General negative regulator of transcription subunit 4

1

2

High-throughput

0.501

High

425103

OTC
Ornithine carbamoyltransferase

1

0

High-throughput

0.493

High

636651

YK50
Mitochondrial hydrolase YKR070W

1

0

High-throughput

0.493

High

636685

URH1
Uridine nucleosidase

1

0

High-throughput

0.493

High

636694

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.493

High

150258

RPN13
26S proteasome regulatory subunit RPN13

1

1

High-throughput

0.479

High

584886

TRM1
tRNA

1

1

High-throughput

0.479

High

603004

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

626580

HSP60
Heat shock protein 60, mitochondrial

1

6

Small-scale

0.479

High

636635

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

636636

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

636644

RAD23
UV excision repair protein RAD23

1

20

High-throughput

0.479

High

636655

HSM3
DNA mismatch repair protein HSM3

1

1

Small-scale

0.479

High

636660

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

1

High-throughput

0.479

High

636665

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

636666

RPN3
26S proteasome regulatory subunit RPN3

1

7

High-throughput

0.479

High

636671

MLP2
Protein MLP2

1

1

High-throughput

0.479

High

636675

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

13

High-throughput

0.479

High

636680

APJ1
J domain-containing protein APJ1

1

7

High-throughput

0.479

High

636683

TOM1
E3 ubiquitin-protein ligase TOM1

1

11

High-throughput

0.479

High

636684

RPN9
26S proteasome regulatory subunit RPN9

1

11

High-throughput

0.479

High

636689

RPN7
26S proteasome regulatory subunit RPN7

1

20

High-throughput

0.479

High

636693

RPN8
26S proteasome regulatory subunit RPN8

1

20

High-throughput

0.479

High

636653

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

1

1

High-throughput

0.470

High

314840

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.458

High

439504

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.458

High

636648

MTR2
mRNA transport regulator MTR2

1

0

High-throughput

0.458

High

636661

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

636672

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

636679

CAF40
Protein CAF40

1

0

High-throughput

0.458

High

636686

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

636697

UTP23
rRNA-processing protein UTP23

1

0

High-throughput

0.458

High

392218

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.445

High

523043

HSP71
Heat shock protein SSA1

1

10

High-throughput

0.445

High

636623

UBA1
Ubiquitin-activating enzyme E1 1

1

3

High-throughput

0.445

High

636634

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

636652

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

636663

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.437

High

636664

ATC3
Phospholipid-transporting ATPase DRS2

1

3

High-throughput

0.437

High

636690

UTP4
U3 small nucleolar RNA-associated protein 4

1

3

High-throughput

0.437

High

464651

AMYG
Glucoamylase, intracellular sporulation-specific

1

0

High-throughput

0.269

Low

597381

EF3A
Elongation factor 3A

1

0

High-throughput

0.269

Low

636641

DCG1
Protein DCG1

1

0

High-throughput

0.269

Low

636676

ASK10
Activator of SKN7 protein 10

1

0

High-throughput

0.269

Low

636688

ATG38
PtdIns3K complex I subunit atg38

1

0

High-throughput

0.269

Low

511538

RL44B
Large ribosomal subunit protein eL42B

1

0

High-throughput

0.249

Low

636677

USE1
Protein transport protein USE1

1

0

High-throughput

0.249

Low

636681

DDR2
Protein DDR2

1

0

High-throughput

0.249

Low

636692

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025