HitPredict

Interactor 1: PSA2 (P25787)
Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3) (Proteasome subunit alpha-2) (alpha-2)
Gene: PSMA2

Interactor 2: PSA6 (P60900)
Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1)
Gene: PSMA6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.986

The method score is based on:

Property Details
Experiments 33961781, 35575683, 38334954, 39358380, 34535262, 40437099, 16759355, 12376572, 19193609, 15887188, 27465334, 35271311, 34349018, 28524877, 31839598, 14733938, 17948026
Identification Methods affinity chromatography technology, cross-linking study, biochemical, pull down, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms GO:0000502 - proteasome complex
GO:0000932 - P-body
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 5 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 234
Hs

1 246
+ Sp
+ Zm
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ss
+ Hs
+ Hs
+ Hs
+ Hs
+ Hv
+ Ce
+ Zm

Service provided by Combinatics, Japan

Last updated: 11Aug2025