HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	9409737, 9362451
Identification Methods	two hybrid, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 147
+	Hs
		639719 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		639710 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		1206094 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84
+	Hs
		829062 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		UBE2A_HUMAN (2-144): 2.83e-70: 209: 40.56
+	Hs
		849363 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		UB2D1_HUMAN (1-147): 3.24e-82: 239: 100.00
+	Hs
		919776 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		883463 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83
+	Hs
		895841 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		896542 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83
+	Hs
		587507 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		587492 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		896486 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83