HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: NEDD8 (Q15843)
NEDD8 (Neddylin) (Neural precursor cell expressed developmentally down-regulated protein 8) (NEDD-8) (Ubiquitin-like protein Nedd8)
Gene: NEDD8

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	10713156
Identification Methods	anti tag coimmunoprecipitation, enzymatic study
Interaction Type	physical association, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 81
+	Dr
		47653 A0AR23_DANRE (6-314): 4.5e-70: 236: 21.61		Q7SXA3_DANRE (1-77): 5.35e-37: 122: 57.14
+	Dr
		47648 A0AR23_DANRE (6-314): 4.5e-70: 236: 21.61		Q3B7P7_DANRE (1-76): 3.36e-33: 112: 57.90
+	Hs
		474996 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90
+	Hs
		924341 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		587511 NFKB1_HUMAN (31-196): 3.47e-20: 93.1: 23.35		RL40_HUMAN (1-76): 3.79e-33: 112: 57.90
+	Hs
		1079539 MIB1_HUMAN (187-313): 7.22e-23: 101: 18.11		NEDD8_HUMAN (1-81): 2.07e-30: 103: 100.00
+	Hs
		475034 IKBB_HUMAN (68-169): 5.17e-13: 70.8: 28.16		UBB_HUMAN (1-76): 2.4e-30: 107: 57.90