HitPredict

Interactor 1: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	0.60	0.769

Property	Details
Experiments	10497169, 20851351, 29499133, 9990853, 10066435, 9859996, 19933270, 20797629, 20558726, 9990852, 25190485, 10713156, 20638939, 25900982, 27001857, 10644755, 32051583, 17319651, 10075690, 20353940 and 9 others more... 22022389, 22590978, 22388891, 19053519, 11027288, 24464578, 24912152, 11850407, 11158290
Identification Methods	affinity chromatography technology, protein complementation assay, pull down, unspecified method, enzymatic study, proximity labelling technology, two hybrid, x-ray crystallography, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, direct interaction, association, ubiquitination reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0038061 - non-canonical NF-kappaB signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 605
+	Mm
		1112935 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		121606 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		222603 IKBE_MOUSE (70-315): 8.59e-76: 238: 36.00		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		961451 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		639819 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		883676 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1330889 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		1131318 IKBA_MOUSE (1-317): 2.2e-78: 243: 91.17		FBW1B_MOUSE (96-605): 2.25e-143: 428: 85.69
+	Hs
		121601 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		961443 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		862124 DAPK1_HUMAN (27-317): 1.12e-62: 216: 17.11		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		72802 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		B4DH70_HUMAN (98-605): 6.62e-144: 428: 85.63
+	Hs
		883666 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1330876 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1302644 Q96T11_HUMAN (136-316): 4.96e-33: 130: 23.76		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		639784 IKBA_HUMAN (1-317): 2.59e-84: 258: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		961417 NFKB2_HUMAN (68-294): 6.66e-64: 218: 34.32		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		121550 IKBE_HUMAN (3-315): 1.28e-74: 239: 32.10		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66
+	Hs
		883544 RIPK4_HUMAN (136-316): 6.43e-34: 133: 24.31		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		1163035 Q9H4D1_HUMAN (136-316): 1.24e-33: 132: 24.31		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12