Protein: LEF1
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)

Gene: LEF1
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9UJU2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

765098

CTNB1
Catenin beta-1

29

20

Small-scale

0.992

High

1458346

NLK
Serine/threonine-protein kinase NLK

5

7

Small-scale

0.710

High

269122

MITF
Microphthalmia-associated transcription factor

3

10

Small-scale

0.682

High

1396941

ANM6
Protein arginine N-methyltransferase 6

3

2

High-throughput

0.662

High

1014650

SMAD3
Mothers against decapentaplegic homolog 3

2

20

Small-scale

0.646

High

1047882

TLE1
Transducin-like enhancer protein 1

2

20

Small-scale

0.635

High

1153941

SMAD2
Mothers against decapentaplegic homolog 2

2

20

Small-scale

0.624

High

1357996

RN138
E3 ubiquitin-protein ligase RNF138

2

14

Small-scale

0.624

High

577921

PLAK
Junction plakoglobin

1

20

Small-scale

0.618

High

604761

UBF1
Nucleolar transcription factor 1

1

20

Small-scale

0.618

High

629515

PO3F2
POU domain, class 3, transcription factor 2

1

20

Small-scale

0.618

High

668746

APC
Adenomatous polyposis coli protein

1

13

Small-scale

0.618

High

1446892

TF7L2
Transcription factor 7-like 2

1

19

Small-scale

0.618

High

177727

SMAD7
Mothers against decapentaplegic homolog 7

2

20

Small-scale

0.601

High

1156712

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.582

High

1067811

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.578

High

1324610

PIAS4
E3 SUMO-protein ligase PIAS4

1

11

Small-scale

0.573

High

613219

EGR1
Early growth response protein 1

2

16

Small-scale

0.571

High

868399

CDX1
Homeobox protein CDX-1

1

20

Small-scale

0.561

High

1447191

KMT5A
N-lysine methyltransferase KMT5A

1

13

Small-scale

0.561

High

1460044

NARF
Nuclear prelamin A recognition factor

2

0

Small-scale

0.559

High

890276

FHIT
Bis(5'-adenosyl)-triphosphatase

1

1

Small-scale

0.554

High

170413

AURKA
Aurora kinase A

1

14

High-throughput

0.541

High

224176

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

9

High-throughput

0.541

High

442828

RB
Retinoblastoma-associated protein

1

3

High-throughput

0.541

High

827518

MLH1
DNA mismatch repair protein Mlh1

1

1

High-throughput

0.541

High

846697

MSH2
DNA mismatch repair protein Msh2

1

2

High-throughput

0.541

High

1154473

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.541

High

1434620

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

20

High-throughput

0.541

High

1459789

MLH3
DNA mismatch repair protein Mlh3

1

1

High-throughput

0.541

High

465687

IGF1R
Insulin-like growth factor 1 receptor

1

3

Small-scale

0.536

High

1406452

PITX2
Pituitary homeobox 2

1

20

Small-scale

0.527

High

1060139

BAX
Apoptosis regulator BAX

1

0

High-throughput

0.518

High

857582

NOTC1
Neurogenic locus notch homolog protein 1

1

4

Small-scale

0.501

High

1047944

TLE2
Transducin-like enhancer protein 2

1

20

Small-scale

0.501

High

1106741

SMAD4
Mothers against decapentaplegic homolog 4

1

20

Small-scale

0.501

High

1290185

THOC4
THO complex subunit 4

1

9

Small-scale

0.501

High

543549

VDR
Vitamin D3 receptor

1

18

Small-scale

0.500

High

374269

RASN
GTPase NRas

1

5

High-throughput

0.494

High

1158721

DPYL2
Dihydropyrimidinase-related protein 2

1

2

High-throughput

0.494

High

143314

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

208586

PJA2
E3 ubiquitin-protein ligase Praja-2

1

3

Small-scale

0.479

High

340949

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

11

High-throughput

0.479

High

474358

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

519434

MYB
Transcriptional activator Myb

1

5

Small-scale

0.479

High

630082

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

838396

STA5A
Signal transducer and activator of transcription 5A

1

1

Small-scale

0.479

High

890228

HINT1
Adenosine 5'-monophosphoramidase HINT1

1

1

Small-scale

0.479

High

1029166

E2F1
Transcription factor E2F1

1

5

Small-scale

0.479

High

1088086

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1106388

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

9

High-throughput

0.479

High

1110164

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

1133723

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1139159

DAZP2
DAZ-associated protein 2

1

4

Small-scale

0.479

High

1154022

SMAD1
Mothers against decapentaplegic homolog 1

1

20

Small-scale

0.479

High

1232992

OTU7B
OTU domain-containing protein 7B

1

5

Small-scale

0.479

High

1452541

DACT1
Dapper homolog 1

1

7

Small-scale

0.479

High

1458703

RNF14
E3 ubiquitin-protein ligase RNF14

1

1

Small-scale

0.479

High

1460640

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

Small-scale

0.479

High

1460641

RUVB1
RuvB-like 1

1

8

Small-scale

0.479

High

1435422

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1092722

AF1Q
Protein AF1q

1

1

Small-scale

0.457

High

587250

ITF2
Transcription factor 4

1

5

Small-scale

0.445

High

932008

EPHB4
Ephrin type-B receptor 4

1

2

Small-scale

0.437

High

1042717

KIME
Mevalonate kinase

1

0

High-throughput

0.279

Low

818841

TYRP2
L-dopachrome tautomerase

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025