HitPredict

Interactor 1: DNMT1 (P26358)
DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT)
Gene: DNMT1

Interactor 2: UHRF1 (Q96T88)
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1)
Gene: UHRF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 26065575, 27045799, 29691401, 31322780, 33465813, 17934516, 36942812, 21745816, 21045206, 22064703, 17673620, 20613874, 28803780, 29268763, 33170271, 36302855, 19800870, 21268065, 24368767, 24782312 and 1 others

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Identification Methods affinity chromatography technology, pull down, fluorescent resonance energy transfer, two hybrid, enzymatic study, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains BAH~PHD, DNMT1-RFD~ubiquitin
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005657 - replication fork
GO:0008270 - zinc ion binding
and 2 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1616
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024