HitPredict

Interactor 1: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Interactor 2: MTMR1 (Q13613)
Phosphatidylinositol-3-phosphate phosphatase MTMR1 (EC 3.1.3.-) (Myotubularin-related protein 1) (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95)
Gene: MTMR1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1342 Hs			1 665
+	Hs
		641592 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		MTMR2_HUMAN (33-665): 0: 890: 69.72
+	Hs
		641648 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		MTMR8_HUMAN (95-662): 0: 707: 36.24
+	Hs
		641707 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		MTMR6_HUMAN (109-660): 0: 688: 34.64
+	Hs
		641659 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		MTMR9_HUMAN (108-652): 0: 663: 35.03
+	Hs
		1112404 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		MTMR2_HUMAN (33-665): 0: 890: 69.72
+	Hs
		641690 ERBB3_HUMAN (1-1342): 0: 1390: 100.00		MTMRA_HUMAN (96-648): 2.38e-165: 494: 23.82
+	Hs
		1145796 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		MTMR6_HUMAN (109-660): 0: 688: 34.64
+	Hs
		1145769 ERBB4_HUMAN (1-1162): 0: 1154: 50.94		MTMR9_HUMAN (108-652): 0: 663: 35.03
+	Hs
		363700 EGFR_HUMAN (18-1211): 0: 1060: 40.65		MTMR8_HUMAN (95-662): 0: 707: 36.24
+	Hs
		364048 EGFR_HUMAN (18-1211): 0: 1060: 40.65		MTMR6_HUMAN (109-660): 0: 688: 34.64
+	Hs
		363738 EGFR_HUMAN (18-1211): 0: 1060: 40.65		MTMR9_HUMAN (108-652): 0: 663: 35.03
+	Hs
		1034227 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		MTMR1_HUMAN (1-665): 0: 969: 100.00
+	Hs
		710229 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		MTMR1_HUMAN (1-665): 0: 969: 100.00
+	Hs
		1034228 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		MTMR2_HUMAN (33-665): 0: 890: 69.72
+	Hs
		710230 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		MTMR2_HUMAN (33-665): 0: 890: 69.72
+	Hs
		1034382 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		MTMR6_HUMAN (109-660): 0: 688: 34.64
+	Hs
		1034322 ROR2_HUMAN (491-1088): 8.52e-118: 393: 20.22		MTMR9_HUMAN (108-652): 0: 663: 35.03
+	Hs
		331715 EPHA2_HUMAN (665-996): 2e-104: 357: 29.40		MTMR5_HUMAN (331-600): 4.06e-94: 321: 30.90
+	Hs
		62288 EPHA3_HUMAN (691-978): 1.42e-41: 168: 34.13		MTMRB_HUMAN (62-588): 1.57e-116: 366: 23.84