HitPredict

Interactor 1: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 513 Hs			1 618
+	Hs
		738320 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22
+	Hs
		738321 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		545365 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Mm
		983317 TGFR2_MOUSE (54-493): 2.59e-120: 366: 35.19		RAC2_MOUSE (3-183): 1.62e-79: 251: 26.67
+	Hs
		739935 TGFR2_HUMAN (28-493): 8.82e-123: 372: 33.79		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		892361 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RAC3_HUMAN (3-168): 9.6e-79: 249: 27.22
+	Hs
		893991 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		CDC42_HUMAN (3-172): 5.67e-77: 244: 25.54
+	Hs
		950982 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOG_HUMAN (3-170): 1.68e-74: 238: 27.47
+	Hs
		925266 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RAC1_HUMAN (3-181): 3.15e-74: 237: 26.43
+	Hs
		564416 AVR2A_HUMAN (1-513): 1.29e-154: 452: 100.00		RHOQ_HUMAN (5-169): 2.02e-10: 62.8: 26.26
+	Hs
		738323 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		738322 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		436181 BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		915666 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOB_HUMAN (6-168): 4.57e-13: 70.1: 29.38
+	Hs
		900458 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOA_HUMAN (6-168): 1.74e-11: 65.5: 28.25
+	Hs
		1046387 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOF_HUMAN (2-167): 3.37e-11: 65.1: 26.67
+	Hs
		436293 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25
+	Hs
		120428 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		564520 BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89		RHOQ_HUMAN (5-169): 2.02e-10: 62.8: 26.26
+	Hs
		436183 TGFR1_HUMAN (60-488): 5.17e-120: 363: 32.31		RHOC_HUMAN (6-168): 3.86e-11: 64.3: 28.25