Protein: SPAST
Spastin (EC 5.6.1.1) (Spastic paraplegia 4 protein)

Gene: SPAST
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q9UBP0

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000922 - spindle pole
GO:0001578 - microtubule bundle formation
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

925689

IST1
IST1 homolog

4

8

Small-scale

0.696

High

1445998

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

5

High-throughput

0.691

High

916054

NUP98
Nuclear pore complex protein Nup98-Nup96

3

8

High-throughput

0.662

High

945322

NU107
Nuclear pore complex protein Nup107

3

2

High-throughput

0.662

High

1339014

NUP43
Nucleoporin Nup43

3

14

High-throughput

0.662

High

1356948

NU133
Nuclear pore complex protein Nup133

3

0

High-throughput

0.634

High

1415841

NUP85
Nuclear pore complex protein Nup85

3

0

High-throughput

0.634

High

1458588

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

2

15

High-throughput

0.628

High

1433462

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

11

High-throughput

0.621

High

425665

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.618

High

935232

TERA
Transitional endoplasmic reticulum ATPase

1

19

High-throughput

0.618

High

1458582

SPAST
Spastin

1

18

High-throughput

0.618

High

1273185

CHM1B
Charged multivesicular body protein 1b

2

20

Small-scale

0.597

High

944091

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

11

High-throughput

0.590

High

1458584

FXL17
F-box/LRR-repeat protein 17

1

3

Small-scale

0.578

High

1085302

NU160
Nuclear pore complex protein Nup160

2

0

High-throughput

0.576

High

1360587

ATLA1
Atlastin-1

1

5

Small-scale

0.573

High

221889

CHM2A
Charged multivesicular body protein 2a

1

20

High-throughput

0.536

High

390204

ALBU
Albumin

1

2

High-throughput

0.536

High

483244

CLCA
Clathrin light chain A

1

5

High-throughput

0.536

High

539644

PYGM
Glycogen phosphorylase, muscle form

1

3

High-throughput

0.536

High

584158

FOSL2
Fos-related antigen 2

1

1

High-throughput

0.536

High

867481

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

966977

1433G
14-3-3 protein gamma

1

12

High-throughput

0.536

High

970151

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1049870

1433F
14-3-3 protein eta

1

12

High-throughput

0.536

High

1154777

VAMP3
Vesicle-associated membrane protein 3

1

1

High-throughput

0.536

High

1252785

RN111
E3 ubiquitin-protein ligase Arkadia

1

7

High-throughput

0.536

High

1307333

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

1322387

PGAM4
Probable phosphoglycerate mutase 4

1

7

High-throughput

0.536

High

1360517

PSPC1
Paraspeckle component 1

1

11

High-throughput

0.536

High

1399402

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

2

High-throughput

0.536

High

1433102

CHM4B
Charged multivesicular body protein 4b

1

17

High-throughput

0.536

High

1458586

PLAL2
Zinc finger protein PLAGL2

1

2

High-throughput

0.536

High

336503

SVIL
Supervillin

1

4

High-throughput

0.515

High

691630

IF
Cobalamin binding intrinsic factor

1

0

High-throughput

0.513

High

1016389

SERF2
Small EDRK-rich factor 2

1

0

High-throughput

0.513

High

186096

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.501

High

998085

CSK21
Casein kinase II subunit alpha

1

7

Small-scale

0.501

High

1215378

DCAF8
DDB1- and CUL4-associated factor 8

1

9

Small-scale

0.501

High

1458587

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

6

Small-scale

0.501

High

600534

ZNF30
Zinc finger protein 30

1

0

High-throughput

0.493

High

1013349

HTRA4
Serine protease HTRA4

1

3

High-throughput

0.489

High

409111

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

High-throughput

0.479

High

791796

SYUA
Alpha-synuclein

1

5

High-throughput

0.479

High

992365

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

995326

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.479

High

1109410

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

3

Small-scale

0.479

High

1112759

CUL1
Cullin-1

1

15

Small-scale

0.479

High

1141995

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

1255930

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.479

High

1434130

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.479

High

1454761

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.479

High

1458585

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1212772

ZFY27
Protrudin

1

0

Small-scale

0.458

High

47594

RPSA2
Small ribosomal subunit protein uS2B

1

5

High-throughput

0.445

High

175445

PLXB2
Plexin-B2

1

2

High-throughput

0.445

High

1339096

NUP37
Nucleoporin Nup37

1

9

High-throughput

0.445

High

1458583

KS6B2
Ribosomal protein S6 kinase beta-2

1

6

High-throughput

0.445

High

106787

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

887292

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

191979

TEX28
Testis-specific protein TEX28

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025