Protein: NEK2
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)

Gene: NEK2
Organism: Homo sapiens
Interactions: 125
UniProt ID: P51955

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0000794 - condensed nuclear chromosome
GO:0000922 - spindle pole
GO:0001824 - blastocyst development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

908803

NEK2
Serine/threonine-protein kinase Nek2

3

19

Small-scale

0.853

High

703507

MK01
Mitogen-activated protein kinase 1

1

12

Small-scale

0.740

High

718522

CDC27
Cell division cycle protein 27 homolog

6

11

Small-scale

0.730

High

241150

PRKN
E3 ubiquitin-protein ligase parkin

1

14

Small-scale

0.724

High

908836

KIF24
Kinesin-like protein KIF24

1

12

Small-scale

0.715

High

908840

NEK11
Serine/threonine-protein kinase Nek11

1

19

Small-scale

0.715

High

908820

CDC16
Cell division cycle protein 16 homolog

5

12

Small-scale

0.712

High

908871

APC4
Anaphase-promoting complex subunit 4

6

0

Small-scale

0.699

High

908868

CDC23
Cell division cycle protein 23 homolog

4

12

Small-scale

0.694

High

658873

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

4

Small-scale

0.692

High

786460

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

4

19

Small-scale

0.686

High

908819

CDC20
Cell division cycle protein 20 homolog

4

8

Small-scale

0.683

High

908870

APC5
Anaphase-promoting complex subunit 5

4

1

Small-scale

0.683

High

908872

ANC2
Anaphase-promoting complex subunit 2

4

10

Small-scale

0.683

High

908874

FZR1
Fizzy-related protein homolog

4

7

Small-scale

0.680

High

163912

NDC80
Kinetochore protein NDC80 homolog

3

20

Small-scale

0.664

High

764562

CTNB1
Catenin beta-1

2

5

Small-scale

0.661

High

908878

GIT1
ARF GTPase-activating protein GIT1

1

11

High-throughput

0.656

High

908856

APC1
Anaphase-promoting complex subunit 1

3

1

Small-scale

0.633

High

908869

APC7
Anaphase-promoting complex subunit 7

3

11

Small-scale

0.633

High

908823

BFSP2
Phakinin

2

4

High-throughput

0.628

High

659411

CRCM
Colorectal mutant cancer protein

2

18

High-throughput

0.625

High

908841

CDC26
Anaphase-promoting complex subunit CDC26

3

0

High-throughput

0.622

High

908843

DTD1
D-aminoacyl-tRNA deacylase 1

2

1

High-throughput

0.621

High

171205

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

7

Small-scale

0.618

High

172051

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

17

Small-scale

0.618

High

175861

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.618

High

468203

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.618

High

650655

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

17

Small-scale

0.618

High

729189

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

9

Small-scale

0.618

High

908804

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

9

Small-scale

0.618

High

908829

SF3B3
Splicing factor 3B subunit 3

1

4

Small-scale

0.618

High

908833

ACTBL
Beta-actin-like protein 2

1

16

Small-scale

0.618

High

908844

LRC15
Leucine-rich repeat-containing protein 15

1

1

Small-scale

0.618

High

908862

ANLN
Anillin

1

3

High-throughput

0.618

High

908865

CALL5
Calmodulin-like protein 5

1

20

Small-scale

0.618

High

908867

ANFY1
Rabankyrin-5

1

5

Small-scale

0.618

High

908854

CP250
Centrosome-associated protein CEP250

2

18

Small-scale

0.606

High

908807

APC15
Anaphase-promoting complex subunit 15

2

0

High-throughput

0.602

High

908813

RHOB
Rho-related GTP-binding protein RhoB

1

17

Small-scale

0.590

High

908848

APC16
Anaphase-promoting complex subunit 16

2

0

High-throughput

0.585

High

571905

TRI27
Zinc finger protein RFP

2

8

Small-scale

0.584

High

187490

FANCA
Fanconi anemia group A protein

1

2

Small-scale

0.573

High

908849

CC85A
Coiled-coil domain-containing protein 85A

2

1

High-throughput

0.570

High

908845

CLC4C
C-type lectin domain family 4 member C

1

1

Small-scale

0.552

High

908880

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

908839

DPP9
Dipeptidyl peptidase 9

1

0

High-throughput

0.513

High

908846

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

908853

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.513

High

447717

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.508

High

908810

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

19

Small-scale

0.508

High

908826

DCTN1
Dynactin subunit 1

1

20

High-throughput

0.508

High

908827

IF4A2
Eukaryotic initiation factor 4A-II

1

11

High-throughput

0.508

High

908837

MYOME
Myomegalin

1

20

High-throughput

0.508

High

908850

IF140
Intraflagellar transport protein 140 homolog

1

4

High-throughput

0.508

High

908857

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

16

High-throughput

0.508

High

908824

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

908860

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.501

High

908855

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.493

High

908832

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.486

High

908852

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.486

High

908842

CIP2A
Protein CIP2A

1

10

Small-scale

0.481

High

251727

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

19

Small-scale

0.479

High

399954

CATA
Catalase

1

2

Small-scale

0.479

High

407841

SEMG1
Semenogelin-1

1

1

Small-scale

0.479

High

408753

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

4

Small-scale

0.479

High

423756

APOD
Apolipoprotein D

1

1

Small-scale

0.479

High

428659

RLA0
Large ribosomal subunit protein uL10

1

3

Small-scale

0.479

High

446789

NPM
Nucleophosmin

1

1

Small-scale

0.479

High

456663

ANXA2
Annexin A2

1

4

Small-scale

0.479

High

474564

VIME
Vimentin

1

14

Small-scale

0.479

High

534813

BIP
Endoplasmic reticulum chaperone BiP

1

19

Small-scale

0.479

High

536792

HSP7C
Heat shock cognate 71 kDa protein

1

15

Small-scale

0.479

High

565832

EF2
Elongation factor 2

1

8

Small-scale

0.479

High

577671

PLAK
Junction plakoglobin

1

5

Small-scale

0.479

High

610271

PRS6A
26S proteasome regulatory subunit 6A

1

12

Small-scale

0.479

High

623206

RO52
E3 ubiquitin-protein ligase TRIM21

1

8

Small-scale

0.479

High

724375

COR1A
Coronin-1A

1

11

Small-scale

0.479

High

724548

S10A7
Protein S100-A7

1

8

Small-scale

0.479

High

732273

PRDX2
Peroxiredoxin-2

1

9

Small-scale

0.479

High

761351

HS71L
Heat shock 70 kDa protein 1-like

1

15

Small-scale

0.479

High

772690

MYH9
Myosin-9

1

17

Small-scale

0.479

High

778637

PRS7
26S proteasome regulatory subunit 7

1

4

Small-scale

0.479

High

801234

HSPA9
Stress-70 protein, mitochondrial

1

20

Small-scale

0.479

High

851271

PRS6B
26S proteasome regulatory subunit 6B

1

4

Small-scale

0.479

High

866619

CAZA2
F-actin-capping protein subunit alpha-2

1

7

Small-scale

0.479

High

908805

CAZA1
F-actin-capping protein subunit alpha-1

1

7

Small-scale

0.479

High

908806

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

908808

IF4A1
Eukaryotic initiation factor 4A-I

1

8

Small-scale

0.479

High

908809

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

Small-scale

0.479

High

908811

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

19

Small-scale

0.479

High

908812

PRS10
26S proteasome regulatory subunit 10B

1

7

Small-scale

0.479

High

908814

H4
Histone H4

1

4

Small-scale

0.479

High

908815

EF1A1
Elongation factor 1-alpha 1

1

5

Small-scale

0.479

High

908816

SEMG2
Semenogelin-2

1

1

Small-scale

0.479

High

908817

DSG1
Desmoglein-1

1

6

Small-scale

0.479

High

908818

DSC1
Desmocollin-1

1

9

Small-scale

0.479

High

908821

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

5

Small-scale

0.479

High

908825

PKP1
Plakophilin-1

1

6

Small-scale

0.479

High

908828

BECN1
Beclin-1

1

2

Small-scale

0.479

High

908834

ODFP2
Outer dense fiber protein 2

1

20

High-throughput

0.479

High

908835

FILA2
Filaggrin-2

1

9

Small-scale

0.479

High

908847

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

7

Small-scale

0.479

High

908851

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.479

High

908858

RNF41
E3 ubiquitin-protein ligase NRDP1

1

15

Small-scale

0.479

High

908861

NRK2
Nicotinamide riboside kinase 2

1

1

Small-scale

0.479

High

908863

OLA1
Obg-like ATPase 1

1

4

Small-scale

0.479

High

908875

APC10
Anaphase-promoting complex subunit 10

1

5

High-throughput

0.479

High

908876

RUVB2
RuvB-like 2

1

6

Small-scale

0.479

High

908877

TR150
Thyroid hormone receptor-associated protein 3

1

7

Small-scale

0.479

High

908879

MYO5A
Unconventional myosin-Va

1

14

Small-scale

0.479

High

908831

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.464

High

484445

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

908822

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.458

High

908830

CDSN
Corneodesmosin

1

0

Small-scale

0.458

High

437480

CASB
Beta-casein

1

2

Small-scale

0.457

High

762227

TRY3
Trypsin-3

1

3

Small-scale

0.437

High

908864

TMOD3
Tropomodulin-3

1

4

Small-scale

0.437

High

908873

COR1C
Coronin-1C

1

10

Small-scale

0.437

High

908838

CP087
UPF0547 protein C16orf87

1

0

High-throughput

0.279

Low

908866

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

531190

CMGA
Chromogranin-A

1

0

High-throughput

0.265

Low

834111

IPP2
Protein phosphatase inhibitor 2

1

0

Small-scale

0.261

Low

908859

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025