HitPredict

Interactor 1: RAD53 (P22216)
Serine/threonine-protein kinase RAD53 (EC 2.7.12.1) (CHEK2 homolog) (Serine-protein kinase 1)
Gene: RAD53

Interactor 2: RHO5 (P53879)
GTP-binding protein RHO5
Gene: RHO5

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37766847
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 821 Sc			1 331
+	Hs
		692027 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		RHOA_HUMAN (5-229): 2.66e-77: 236: 40.89
+	Hs
		692037 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		RAC1_HUMAN (1-229): 2.72e-75: 231: 44.11
+	Hs
		692023 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		RAC3_HUMAN (1-218): 1.77e-72: 224: 44.95
+	Hs
		692041 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		RHOG_HUMAN (1-229): 2.29e-72: 223: 41.92
+	Hs
		580880 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		RAC2_HUMAN (1-228): 8.26e-72: 222: 43.86
+	Hs
		692024 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		CDC42_HUMAN (1-229): 2.85e-70: 218: 44.11
+	Hs
		962195 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		RHOA_HUMAN (5-229): 2.66e-77: 236: 40.89
+	Hs
		988474 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		RAC1_HUMAN (1-229): 2.72e-75: 231: 44.11
+	Hs
		953523 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		RAC3_HUMAN (1-218): 1.77e-72: 224: 44.95
+	Hs
		1015546 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		RHOG_HUMAN (1-229): 2.29e-72: 223: 41.92
+	Hs
		581132 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		RAC2_HUMAN (1-228): 8.26e-72: 222: 43.86
+	Hs
		955482 MARK4_HUMAN (141-820): 5.75e-135: 420: 19.23		CDC42_HUMAN (1-229): 2.85e-70: 218: 44.11
+	Hs
		601178 MARK3_HUMAN (143-821): 8.76e-148: 454: 19.48		RHOQ_HUMAN (4-222): 7.28e-56: 182: 42.92
+	Hs
		955318 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		CDC42_HUMAN (1-229): 2.85e-70: 218: 44.11
+	Hs
		601344 MARK2_HUMAN (141-821): 8.58e-134: 418: 16.85		RHOQ_HUMAN (4-222): 7.28e-56: 182: 42.92
+	Hs
		988370 MELK_HUMAN (200-466): 1.72e-47: 181: 37.92		RAC1_HUMAN (1-229): 2.72e-75: 231: 44.11
+	Hs
		955494 PSKH2_HUMAN (200-491): 1.44e-52: 189: 36.49		CDC42_HUMAN (1-229): 2.85e-70: 218: 44.11
+	Hs
		581052 MELK_HUMAN (200-466): 1.72e-47: 181: 37.92		RAC2_HUMAN (1-228): 8.26e-72: 222: 43.86
+	Hs
		955175 MELK_HUMAN (200-466): 1.72e-47: 181: 37.92		CDC42_HUMAN (1-229): 2.85e-70: 218: 44.11
+	Hs
		581030 KCC2D_HUMAN (194-466): 5.36e-46: 174: 35.15		RAC2_HUMAN (1-228): 8.26e-72: 222: 43.86