HitPredict

Interactor 1: MYD88 (P22366)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Interactor 2: TIRAP (Q99JY1)
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein)
Gene: TIRAP

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 30108181, 19378012
Identification Methods two hybrid, protein complementation assay
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains TIR_2~TIR_2
Common GO terms GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0007166 - cell surface receptor signaling pathway
GO:0032496 - response to lipopolysaccharide
and 10 others

more...
Homologous interactions 6

Homologous interactions

Color coding for hit scores

1 296
Mm

1 241
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 11Aug2025