HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: CRKL (P46109)
Crk-like protein
Gene: CRKL

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0016477 - cell migration GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 303
+	Mm
		641293 FGFR2_MOUSE (4-797): 0: 722: 56.31		CRKL_MOUSE (1-303): 5.53e-70: 220: 96.70
+	Hs
		541387 FGFR1_HUMAN (3-794): 0: 714: 54.76		CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00
+	Hs
		648454 FGFR4_HUMAN (13-802): 0: 755: 100.00		CRK_HUMAN (3-302): 1.42e-51: 173: 54.89
+	Hs
		541386 FGFR1_HUMAN (3-794): 0: 714: 54.76		CRK_HUMAN (3-302): 1.42e-51: 173: 54.89
+	Hs
		618976 FGFR4_HUMAN (13-802): 0: 755: 100.00		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Hs
		618973 FGFR2_HUMAN (4-797): 0: 748: 56.44		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Hs
		648477 FGFR4_HUMAN (13-802): 0: 755: 100.00		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		641152 FGFR2_HUMAN (4-797): 0: 748: 56.44		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		222019 FGFR4_HUMAN (13-802): 0: 755: 100.00		NCK2_HUMAN (13-98): 9.64e-18: 84.4: 29.89
+	Hs
		648704 FGFR4_HUMAN (13-802): 0: 755: 100.00		ITSN2_HUMAN (73-297): 1.66e-16: 82.1: 16.89
+	Hs
		593910 FGFR4_HUMAN (13-802): 0: 755: 100.00		NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81
+	Hs
		618977 FGFR3_HUMAN (5-799): 0: 720: 61.07		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Hs
		641273 FGFR2_HUMAN (4-797): 0: 748: 56.44		ITSN2_HUMAN (73-297): 1.66e-16: 82.1: 16.89
+	Hs
		541327 FGFR1_HUMAN (3-794): 0: 714: 54.76		PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60
+	Hs
		541319 FGFR1_HUMAN (3-794): 0: 714: 54.76		PLCG2_HUMAN (5-192): 1.58e-26: 111: 18.23
+	Hs
		650120 FGFR3_HUMAN (5-799): 0: 720: 61.07		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		541426 FGFR1_HUMAN (3-794): 0: 714: 54.76		GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89
+	Hs
		222008 FGFR1_HUMAN (3-794): 0: 714: 54.76		NCK2_HUMAN (13-98): 9.64e-18: 84.4: 29.89
+	Hs
		541316 FGFR1_HUMAN (3-794): 0: 714: 54.76		NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81
+	Hs
		541313 FGFR1_HUMAN (3-794): 0: 714: 54.76		VAV_HUMAN (214-293): 4.71e-14: 74.4: 30.86