HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005768 - endosome GO:0005794 - Golgi apparatus GO:0005886 - plasma membrane GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 802 Hs			1 217
+	Hs
		641152 FGFR2_HUMAN (4-797): 0: 748: 56.44		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		650120 FGFR3_HUMAN (5-799): 0: 720: 61.07		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		541426 FGFR1_HUMAN (3-794): 0: 714: 54.76		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		593910 FGFR4_HUMAN (13-802): 0: 755: 100.00		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		648449 FGFR4_HUMAN (13-802): 0: 755: 100.00		ABL2_HUMAN (4-139): 9.65e-22: 94.7: 34.04
+	Hs
		648544 FGFR4_HUMAN (13-802): 0: 755: 100.00		SH319_HUMAN (8-215): 6.01e-18: 83.5: 17.14
+	Hs
		648704 FGFR4_HUMAN (13-802): 0: 755: 100.00		ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92
+	Hs
		648527 FGFR4_HUMAN (13-802): 0: 755: 100.00		ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53
+	Hs
		641273 FGFR2_HUMAN (4-797): 0: 748: 56.44		ITSN2_HUMAN (108-216): 6.53e-13: 69.2: 18.92
+	Hs
		440363 FGFR2_HUMAN (4-797): 0: 748: 56.44		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		463332 FGFR4_HUMAN (13-802): 0: 755: 100.00		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		541476 FGFR1_HUMAN (3-794): 0: 714: 54.76		PTK6_HUMAN (4-141): 7.17e-23: 97.1: 38.93
+	Hs
		541316 FGFR1_HUMAN (3-794): 0: 714: 54.76		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		557090 FGFR2_HUMAN (4-797): 0: 748: 56.44		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		541382 FGFR1_HUMAN (3-794): 0: 714: 54.76		ABL2_HUMAN (4-139): 9.65e-22: 94.7: 34.04
+	Hs
		463329 FGFR2_HUMAN (4-797): 0: 748: 56.44		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		541313 FGFR1_HUMAN (3-794): 0: 714: 54.76		VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37
+	Hs
		462961 FGFR1_HUMAN (3-794): 0: 714: 54.76		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		541509 FGFR1_HUMAN (3-794): 0: 714: 54.76		ITSN1_HUMAN (122-216): 3.21e-11: 64.2: 23.53
+	Hs
		541302 FGFR1_HUMAN (3-794): 0: 714: 54.76		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58