HitPredict

Interactor 1: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Interactor 2: FCGRN (P55899)
IgG receptor FcRn large subunit p51 (FcRn) (IgG Fc fragment receptor transporter alpha chain) (Neonatal Fc receptor)
Gene: FCGRT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.80	0.726

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~Ig_3
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 802 Hs			1 365
+	Hs
		409266 FGFR4_HUMAN (13-802): 0: 755: 100.00		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		409262 FGFR2_HUMAN (4-797): 0: 748: 56.44		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		409236 FGFR1_HUMAN (3-794): 0: 714: 54.76		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		641146 FGFR2_HUMAN (4-797): 0: 748: 56.44		FCGRN_HUMAN (1-365): 1.44e-113: 336: 100.00
+	Hs
		541416 FGFR1_HUMAN (3-794): 0: 714: 54.76		FCGRN_HUMAN (1-365): 1.44e-113: 336: 100.00
+	Hs
		409277 EPHA2_HUMAN (4-789): 0: 587: 19.52		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		520754 EPHA2_HUMAN (4-789): 0: 587: 19.52		HLAC_HUMAN (1-359): 7.04e-131: 380: 25.95
+	Hs
		409354 ROR1_HUMAN (11-777): 2.29e-168: 512: 20.73		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		409396 NTRK3_HUMAN (159-751): 2.57e-165: 501: 25.24		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		409214 NTRK1_HUMAN (135-751): 2.17e-160: 487: 26.53		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		409223 RET_HUMAN (221-802): 2.72e-146: 459: 34.72		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01
+	Hs
		520859 NTRK3_HUMAN (159-751): 2.57e-165: 501: 25.24		HLAC_HUMAN (1-359): 7.04e-131: 380: 25.95
+	Hs
		719713 NTRK3_HUMAN (159-751): 2.57e-165: 501: 25.24		HLAF_HUMAN (4-337): 3.98e-119: 350: 29.02
+	Hs
		179591 MUSK_HUMAN (461-746): 4.4e-66: 238: 43.88		HLAB_HUMAN (1-357): 2.04e-134: 389: 26.63
+	Hs
		179595 MUSK_HUMAN (461-746): 4.4e-66: 238: 43.88		HLAC_HUMAN (1-359): 7.04e-131: 380: 25.95
+	Hs
		409289 VGFR3_HUMAN (153-356): 9.27e-11: 67.8: 18.78		HLAA_HUMAN (1-360): 6.87e-148: 423: 27.01