HitPredict

Interactor 1: P85A (P27986)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: PIK3R1

Interactor 2: FLT3 (P36888)
Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
Gene: FLT3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.776

The method score is based on:

Property Details
Experiments 16982329, 9918857
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0019221 - cytokine-mediated signaling pathway
GO:0030183 - B cell differentiation
GO:0141038 - phosphatidylinositol 3-kinase activator activity
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 724
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024