HitPredict

Interactor 1: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Interactor 2: MAX (P61244)
Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)
Gene: MAX

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1054 Hs			1 160
+	Hs
		607786 SMCA1_HUMAN (1-1054): 0: 1130: 100.00		USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97
+	Hs
		346003 SMCA1_HUMAN (1-1054): 0: 1130: 100.00		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		229350 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		MAX_HUMAN (1-160): 2.05e-31: 112: 100.00
+	Hs
		229308 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97
+	Hs
		229271 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		229276 SMCA5_HUMAN (32-1051): 0: 1065: 81.86		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		347406 CHD5_HUMAN (31-961): 0: 800: 28.13		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		346805 CHD4_HUMAN (29-960): 0: 789: 28.27		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379411 CHD4_HUMAN (29-960): 0: 789: 28.27		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Mm
		348432 CHD4_MOUSE (29-960): 0: 787: 28.27		MYC_MOUSE (19-105): 1.04e-21: 91.9: 37.50
+	Hs
		348113 CHD7_HUMAN (3-1046): 0: 780: 26.74		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379973 CHD7_HUMAN (3-1046): 0: 780: 26.74		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		607839 CHD8_HUMAN (2-1011): 0: 769: 27.72		USF1_HUMAN (10-115): 4.62e-23: 94.1: 30.97
+	Hs
		347951 CHD8_HUMAN (2-1011): 0: 769: 27.72		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		346938 CHD9_HUMAN (2-1019): 0: 741: 26.94		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		151469 CHD2_HUMAN (21-1047): 0: 732: 29.60		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		151473 CHD2_HUMAN (21-1047): 0: 732: 29.60		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67
+	Hs
		151368 CHD1_HUMAN (5-1050): 0: 695: 29.33		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		346268 SMCA4_HUMAN (60-913): 0: 686: 31.42		MYC_HUMAN (14-105): 1.81e-21: 91.5: 34.74
+	Hs
		379142 SMCA4_HUMAN (60-913): 0: 686: 31.42		MYCN_HUMAN (7-101): 2.1e-21: 91.1: 33.67